Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. AUTHOR
      AUTHOR
      all to gain
      No Mood

      all to gain Member

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      Thanks.

      A few more questions (some of which you may have already answered):

      Is there any way that the Hough pill could be fast tracked by the FDA? Frequency Therapeutics has got their FX-322 fast tracked, so there is obviously interest in getting such drugs to the market.

      Do you keep an eye on your competitors, i.e. Frequency Therapeatuics, Otonomy and Pipeline Therapeutics, to see how far along the pipeline they are? How do you feel you compare to them?

      Since funding part of the study, has the DoD shown any interest in getting the pill out sooner rather than later, and if not, why not?

      Like others have said, thank you very much for answering our questions. It is developments like Hough's that keep some of us motivated to fight the battle another day. Glad I started the thread and you started posting.
       
      • Good Question Good Question x 3
      • Winner Winner x 1
    2. WickedCarnival

      WickedCarnival Member

      Tinnitus Since:
      Late Autumn 2016
      Cause of Tinnitus:
      Unsure between azithromycin or viral infection
      Hi Justin! Have you been in contact with anyone from Frequency Therapeutics? As much as I understand there is competition in biotech markets, hearing loss and tinnitus are a devastating global phenomenon that may be better tackled with a collaborative effort. Sharing research between organizations in my opinion would help speed up things for the benefit of everyone.

      Also, have you heard of Otomagnetics delivery methods of inner ear drugs? https://otomagnetics.net/about
       
      • Good Question Good Question x 1
    3. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      I really don't know. There are too many factors to be considered. Sorry.
       
    4. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Yes, it is being fast-tracked. The hold up was funding Phase II and possibly III. That is no longer the issue.

      I don't, but the researchers do keep up on the latest research. Each of them is approaching the problem from their own unique perspective. This is good because that means there are that many more chances that something will work and get approved. If we are super lucky, they will all be approved. This is good because hearing loss and tinnitus are different for everyone. Our pill might work for one set of patients, while the injection that Frequency Therapeutics is working on might work with another.

      No, the DoD rarely funds clinical trials in Phase II and III.
       
      • Like Like x 1
      • Informative Informative x 1
    5. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      We have not. Because of the competition, patents, and they are a for-profit v. a non-profit like us - there won't be any collaboration. Never will be. Our philosophies are entirely different. Our motivation is not money, it's you. A good example of that is how much I'm on here and the kind of response people have received from Hough Ear Institute. Others have shared that they haven't received anything like this from Frequency Therapeutics, or any other research firm.

      I agree, sharing research would be ideal, but in the real world, it will rarely happen.
       
      • Like Like x 6
      • Agree Agree x 1
    6. WickedCarnival

      WickedCarnival Member

      Tinnitus Since:
      Late Autumn 2016
      Cause of Tinnitus:
      Unsure between azithromycin or viral infection
      Thank you for your response I really appreciate it! Although I am in a desperate position to jump with the first treatment that comes out, my core beliefs and views align with the models of non-profit organizations. Since I'm from Canada, I'm also curious about what the process would be like once you receive further FDA approval for additional trials and how that can be translated to getting treatment to both the U.S and Canada. I heard that if there is enough data and good results, Health Canada can expedite their process for breakthrough therapies as well, though I would need further information.

      A technical question I have would be on the pill delivery method. How does enough of the drug in the capsule get from the bloodstream into the inner ear in order to deliver enough molecules to trigger the desired response?
       
      • Good Question Good Question x 2
    7. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      Hi Justin I wanted to ask that I got tinnitus because of loud music do you know what type of damaged I did to myself? Also how will this help people who’s tinnitus was caused because of excessive headphone/earphone use on loud volume?
       
      • Good Question Good Question x 2
    8. Mistertdog15

      Mistertdog15 Member

      Tinnitus Since:
      march2020
      Cause of Tinnitus:
      ciprofloxacin
      Will Hough Ear Institute's pill benefit people with nerve damage or hair cell damage from ototoxic medication?

      @Justin De Moss
       
      • Good Question Good Question x 2
    9. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      I think I can answer that. Excessive noise can burn out the synaptic ribbons in the ear, which is believed to be associated with hidden hearing loss (difficulty in understanding words in background noise), as well as tinnitus. The pill would regenerate that. If I recall correctly, it would also supposedly regenerate some regular hearing as well, but only slightly, like an "earmuff" worth, which I believe would be around 5-10 dB.

      Unfortunately the pill would not regenerate the noise damage done to hair cells. That's where the other drug they are working on comes in.
       
      • Hug Hug x 1
      • Informative Informative x 1
    10. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      I still find it really astonishing that a pill would do so much good. It's a shame that so much work has to go into them and that they're not a natural thing. Would love to just be able to just grab it at a grocery store lol.
       
      • Agree Agree x 3
    11. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      The pill does not address hair cell damage. If you had synaptic damage, I'm not sure the cause would matter but maybe @Justin De Moss knows something we don't.
       
    12. hans799
      Mellow

      hans799 Member Benefactor

      Location:
      Hungary
      Tinnitus Since:
      Born with it
      Cause of Tinnitus:
      Worsened Dec 2016 by headphones
      From one perspective, it's incredibly frustrating that this already exists but I just can't get to it.

      However... from another perspective, it's incredibly relieving that this already exists here in this physical reality, and is no longer just an idea on a drawing board which may or may not work. :) In an earlier thread, someone was imagining a future where tinnitus is like many illnesses today... you think to yourself "it sure must have sucked a hundred years ago when this had no treatment" as you walk to the pharmacy to get your pills which will cure you in a few days. Maybe this future is closer than we think!

      Thanks for all you do @Justin De Moss!
       
      • Like Like x 1
      • Hug Hug x 1
      • Optimistic Optimistic x 1
    13. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      Wow you answered my questions that other people haven’t been able too also it doesn’t feel like I lost hearing so I bet I have hidden hearing lost. thank you so much I hope their pill is a success
       
    14. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      I'm confident it works. It's just a matter of funding, though thankfully things seem to be okay now.
       
      • Agree Agree x 1
    15. ASilverLight
      In pain

      ASilverLight Member

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      That's the question.
      I'm just wondering how likely this is to work if you have no measurable/detectable hearing loss and don't appear to have hidden hearing loss? I don't show or struggle with any of the defining characteristics of hidden hearing loss. I am aware there may still be damage that I am not aware of.

      This is more of a general question too, but how many of these treatments will bring relief to people who may have inexplicable tinnitus, or tinnitus through other issues (like neck problems)?
       
      • Good Question Good Question x 2
    16. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Hidden hearing loss will only show up as speech in noise issues if it affects enough important speech frequencies. Unfortunately, there isn't great testing for it.

      Extended audiograms are better for detecting "measurable" hearing loss due to hair cell loss and tinnitus is often at these higher frequencies.

      Noise can cause either synaptopathy or hair cell loss but the synapses tend to be more sensitive. You can also have both and have a normal standard audiogram.

      These regenerative treatments will only treat cochlear causes. So neck and jaw related tinnitus won't be helped but there are treatments that directly help those (and possibly indirect treatments with things like better bimodal stimulation).
       
      • Agree Agree x 2
      • Useful Useful x 1
    17. ASilverLight
      In pain

      ASilverLight Member

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      That's the question.
      Thanks, that's about what I figured. Everyone has a degree of hearing loss naturally, I have no issue with speech etc in noise besides what one would consider normal. I suppose there may be some hearing loss in the higher frequencies that is too minor to detect, but I genuinely have no hearing issues that I am aware of.

      I wish I could get better treatment for my neck issues but it's impossible right now and worrying me a lot. I do wonder if bimodal stimulation is going to be useful if my noises are hard to match to frequencies but I haven't read into it enough.

      Anyway, I won't derail this topic too much. I do hope this, or any pill, may restore whatever damage has been done which will hopefully quieten things some if treating my neck doesn't. Thanks for your response!
       
      • Hug Hug x 1
      • Genius Genius x 1
    18. Tweedleman
      Depressed

      Tweedleman Member Benefactor

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Unknown/Noise
      This is what I'm wondering too. As I understood it, the BLB (blood-labyrinth barrier) is the big obstacle for delivering medicine vascularly to the inner ear.

      https://stm.sciencemag.org/content/11/482/eaao0935

      @Justin De Moss How does the Hough Pill overcome this?
       
      • Good Question Good Question x 2
      • Like Like x 1
    19. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Our pill regenerates meaningful nerve connections between the cochlea and the auditory nerve.

      Our hearing restoration injection regenerates the hair cells in the inner ear.
       
      • Like Like x 2
      • Helpful Helpful x 1
    20. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      A little more like 10-15 dB :) It Sounds like we might have found another spokesperson!

      I am very grateful for all of your questions, support, and your desire to end tinnitus!
       
      • Like Like x 6
    21. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      You are most welcome! Thank you for your support.
       
      • Friendly Friendly x 2
      • Like Like x 1
    22. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Thanks but, just to clarify, my comment-question was about whether the cause of synaptic loss matters, not what the pill vs the injection treats.
       
    23. WickedCarnival

      WickedCarnival Member

      Tinnitus Since:
      Late Autumn 2016
      Cause of Tinnitus:
      Unsure between azithromycin or viral infection
      Since I am not able to access clinical extended high frequency audiograms up to 16kHz, I can only guess that my tinnitus plus ear fullness (verified no physical blockage, wax, nor fluid) is due to damage of the synapses that are attached to high frequency detecting hair cells near the base of the cochlea, but possibly not hair cell death since I can still hear up to 17kHz at my age of 30: https://www.audiocheck.net/audiotests_frequencycheckhigh.php

      I'm very responsible with noise exposure in my life and my tinnitus was caused by an ototoxic antibiotic which I don't know if if affected the synapses or hair cells.

      If it becomes available, could I still take both treatments at the same time and have no adverse effects and possibly a slight improvement beyond 16kHz? I would prefer that for best results because again, nowhere in my area tests hearing up to 16kHz and and I'm a little concerned that under-educated clinicians would say my hearing is fine when they only test up to 8kHz.
       
      • Like Like x 1
    24. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      Even better! That's a huge relief to hear.

      Yoooo, y'all hiring? xD
       
      • Funny Funny x 2
      • Like Like x 1
    25. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Hello @Justin De Moss, thanks for checking in.

      The above question in quotes is very special to me. Looking forward to your response.

      Take care, and thanks again.
      Daniel
       
      • Like Like x 3
    26. Jorge1984
      Wishful

      Jorge1984 Member

      Tinnitus Since:
      02/2020
      Cause of Tinnitus:
      Loud music
      @Justin De Moss how will we test for the synapse disconnection or is that something you guys are trying to figure out?
       
    27. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Ah ha. Sorry about that. I don't believe the cause of the nerve damage matters because the pill has been shown to work with blast-induced trauma, sound-induced trauma, cytotoxicity, etc.
       
      • Like Like x 2
      • Informative Informative x 2
      • Optimistic Optimistic x 1
    28. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      Sorry, I really don't know how to answer this. I have passed on the question to one of our researchers. They may take a bit to get back to me with all the COVID stuff and precautions we are having to take to ensure the safety of our researchers, and that the research continues!
       
      • Like Like x 1
    29. Justin De Moss
      Caffeine

      Justin De Moss Member Benefactor

      Location:
      Oklahoma City, OK
      Tinnitus Since:
      1983
      Cause of Tinnitus:
      My sister, and a firecracker
      I'm not sure about the design study. I don't get that deep into it. I'll ask and see what they say.
       
      • Like Like x 2
    30. Ozwel
      Disappointed

      Ozwel Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Auditive trauma
      Hi Justin, thanks for the excellent communication with all the members here.

      I was being curious: do you plan to test it on yourself anytime soon? Or maybe have you already done that?

      I'm not sure if the pill is still under improvement or if it's just being tested on trial common phases.
       
      • Good Question Good Question x 1
      • Informative Informative x 1

Share This Page

Loading...