Hough Ear Institute's Hair Cell Regeneration Project

Discussion in 'Research News' started by all to gain, Oct 2, 2019.

    1. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      There is more to that organisation than just solely being an ENT practice. I'm pretty sure that there is a whole research arm too that works independently to the actual ENT Practice, much like what happens here already with a number of firms which treat patients and also actually engage in medical research.
       
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    2. Artemis2K
      Kick ass

      Artemis2K Member Benefactor

      Location:
      South Carolina
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I had tinnitus for as long as I can remember. Got bad later.
      If I recall correctly, someone here already has had the ENT there as their own doctor. I don't remember who that was though.
       
    3. OptimusPrimed
      Spaced

      OptimusPrimed Member Benefactor

      Tinnitus Since:
      10/2007
      Cause of Tinnitus:
      Acoustic trauma
      Hough Ear Institute seemed to get a lot of hate on this thread. But they did win a grant from the Department of Defense among 73 other competitors. So they’re either really good at grant writing or they have some solid science behind the pill.

      Keep the faith.
       
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    4. Ali.sy

      Ali.sy Member

      Location:
      Deutschland
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Headphones
      Why doesn't Tesla support this institute if Elon Musk is interested in treating tinnitus? It is my understanding that money is the obstacle to research.
       
      • Good Question Good Question x 2
    5. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I think it's because they don't manage their optics very well in terms of straddling soliciting donations and commercializing a product — it seems like they want to be a non-profit and a commercial venture at the same time which for many is an immediate red flag. I don't think anyone is calling them a scam but it doesn't pass a smell test.

      I'm not saying they are fraudulent, but that dubiousness combined with their PR guy selectively answering questions on here rubbed people the wrong way.
       
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    6. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Tesla is an electric car, battery, and solar manufacturer. Why would a company that makes the above invest in a hearing solution?

      Their CEO, Elon Musk also founded Neuralink which is a tech that he claims may one day address tinnitus.

      Why would either be incentivized to invest in this non-profit?
       
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    7. Ali.sy

      Ali.sy Member

      Location:
      Deutschland
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Headphones
      Elon Musk's wife suffers from hearing loss and tinnitus.
       
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    8. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      There are three things that I think Hough Ear Institute have handled quite negatively and poorly with their dissemination of information relating to their medicines.

      1. Avoiding answering questions on why they have proceeded with completing the proof of concept study work for their pill when they need to obtain more money in order to complete the post study verification of the work.

      2. Avoiding explaining who is going to be the ultimate beneficiaries from the sales of any successful medicines.

      3. Not answering matters on why they need to solicit donations to proceed with work and what such money will get used for.

      No matter how good an idea is, it won't get the support it needs from other sources if they cannot communicate clearly, informatively and transparently with those that are being asked to help.

      Have a look at situations with other companies such as Bouqs Flowers or Echo Valley Meats from the Shark Tank. Both entities pitched their products to the investor group and were turned down because they were not satisfied with the way the product had been demonstrated to them nor with the reasons given to them by the organisations' representatives as to why they should invest.

      It could be that Hough Ear Institute has a great product which turns out to be wonderful, however if they do not put things forward appropriately and do not adequately engage in open communication they are not likely to garner the support they require and/or desire too.

      Thus Hough Ear Institute might be really good at writing grants or they might simply be very poor at communicating with and addressing the questions that are put to them by potential donors such as members of the public.

      Either way there still seems to be legitimate concerns held by people about what they are doing and their way of going about doing it which has led to some individual's apathy towards the organisation.
       
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    9. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Yes, so why invest in this company when he has direct influence in the development of tech that he helped found. Doesn't make any sense.
       
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    10. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
      • Informative Informative x 2
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    11. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      This is great to know. However, there is little information still forthcoming about the business side of the operation, such as whether they still require funding for things that they claim to require like validating the proof of concept study.
       
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    12. Dizzyhead888

      Dizzyhead888 Member Benefactor

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      unknown
      What and when is the next milestone for Hough Ear Institute?
       
    13. Gee82

      Gee82 Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Noise
      I’ve read somewhere them saying the earliest they expect to hit the market is 2027.
       
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    14. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      They did. Though this has then been clarified by them as being a conservative estimate, in order to not understate when they are going to be able to complete it by.
       
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    15. Gee82

      Gee82 Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Noise
      They are at such an early stage that I think estimating a time to market is pure guessing. We have seen recently with Frequency Therapeutics and Otonomy how easily clinical trials can fail therefore delaying their timeline by years.
       
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    16. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Their timeline tends to be consistent with the standard time taken to take a medicine through the procedures to get it out to market.

      They have done Phase 1 already and the proof of concept work is what is required to get the treatment to a point where it can get trialled for effectiveness when taken.

      That being said, I do agree with you that there might be factors which alter its progression.
       
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    17. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
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    18. Mica Rambin

      Mica Rambin Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      NIHL
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    19. SD7
      Angry

      SD7 Member

      Tinnitus Since:
      Left mid May, Right mid June 2021
      Cause of Tinnitus:
      Unsure of left, acoustic right
      How incredible would this be. Eat a pill, see ya later tinnitus.
       
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    20. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      They say they need to raise $125K to move this forward to Phase II? That's a drop in the bucket in the bigger scheme of things and should be no problem to raise instantly if their drug held any promise and they had any confidence in it at all.

      Something doesn't pass the sniff test in my view.
       
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    21. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Duh... Tell 'em: "Sell the pill to Otonomy, Audion or Frequency Therapeutics for $125K dollars. They might use the ideas behind it or find them useful."
       
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    22. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Freaking Bezos spending a half billion dollars for a rocket carnival ride to kinda in space, while people need help. All that money could have been used for good instead of some billionaire getting his rocks off.
       
      • Agree Agree x 14
    23. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      The hearing loss pill consists of NHP-07 and NAC. NHP-07 has already been tested for safety in previous trials, NAC is over the counter so why do we need so many years of trials for NHPN-1010? This system is rotten.
       
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    24. Aleksandar

      Aleksandar Member

      Tinnitus Since:
      09/2020
      Cause of Tinnitus:
      Covid19
      It is a cruel world in which one lives, man is insignificant in it.
       
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    25. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/28/16
      Cause of Tinnitus:
      Shooting/loud noise
      Exactly, all these billionaires doing pointless shit where all they have to do is donate a million and we can all get our lives back.

      If any of these guys were smart, they'd purchase a part of the company or invest.

      We all know if you were a part of the company that made a tinnitus or hearing loss cure, you would make an insane amount of money while helping people.
       
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    26. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      The problem is, they're already stupidly, unfathomably rich beyond any normal comprehension from the investments they've made in their own companies. So rich that they can bootstrap the majority of a private space program for at least a decade!

      So, why bother investing chump change into a hearing loss drug that may/may not pay off for years, and when it does, is like a rounding error in their bank account?

      Also, Space is super sexy and attention/imagination grabbing while restoring hearing is not. Unfortunately.
       
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    27. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      See so this is the same issue that Hough Ear Institute has had throughout their research processes. Pretty positive that the theory is that no matter how good their work might be, they have failed to clearly communicate components of their funding/fundraising methods. This has left people somewhat confused and concerned with where/what the money would be utilised on.

      To date Hough Ear Institute has not adequately explained the following:

      1. Why donations for hearing loss cannot be used towards their tinnitus medicine when it is inevitably also treating hearing loss.

      2. Which parties are going to benefit from the sales of this medicine.

      3. The reason(s) why they need funding from the public and donors towards development of this treatment when it appears on face value that there's two pharma companies who own rights to this treatment if it is successful.

      4. What they need the current gap in their funding for.

      5. What potentially will be given to donors in exchange for donating.

      Simply until these (and possibly other) matters are answered, a lot of people are still going to have queries and concerns about what they are doing as an entity. Essentially the biggest issue with Hough Ear Institute has been the lack of communication from them about these type of key issues and this has been further compounded by the fact that when pressed or queried on such things they seem to either avoid answering them or provide vague answers.

      The end result is that Hough Ear Institute presently reminds me of a car for sale which won't start and the owner can't tell you why. Fix the problem or give answers and it is almost certain that people will be more willing to entertain what is actually being offered.
       
      • Agree Agree x 2
    28. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/28/16
      Cause of Tinnitus:
      Shooting/loud noise
      True, you're right man :( We gotta raise the money, there has to be a few millionaires suffering from tinnitus and hyperacusis. There has to be.
       
      • Agree Agree x 1
    29. Damocles
      No Mood

      Damocles Member

      Location:
      London
      Tinnitus Since:
      04/2009
      Cause of Tinnitus:
      Cumulative Acoustic Trauma + Ear Infection
      No man! What we have to do, is invest in, and create a pair of, SPACE HEADPHONES!! that these rich dudes can wear and use on a daily basis... then we'll see the funding rolling in... :sneaky:
       
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    30. Brian Newman

      Brian Newman Member

      Tinnitus Since:
      12/28/16
      Cause of Tinnitus:
      Shooting/loud noise
      Lmaooooooo Ikr.
       
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