New University of Michigan Tinnitus Discovery — Signal Timing

Discussion in 'Research News' started by Hudson, Jun 20, 2013.

    1. TomBradyGOAT

      TomBradyGOAT Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Who knows
      Um, no. Trigeminal Neuralgia is an issue of the Trigeminal Nerve. So stimulation of the Vagus Nerve would not cause Trigeminal Neuralgia. The Vagus Nerve is much bigger and goes from face to stomach area.
       
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    2. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Yeah, that's what we figured, and that woman had prior nerve issues.

      So you see no risk in these devices stimulating these nerves?
       
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    3. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      New Dr. Susan Shore update!

      Cochlear nucleus small cells use olivocochlear collaterals to encode sounds in noise

      Yet to be peer reviewed.

      She doesn't mention tinnitus upfront, neither in the title nor the abstract, BUT it does appear deeper in the text as well as hyperacusis! That's a surprise.

      The connections she references to tinnitus and hyperacusis are very interesting and become clearer if we take a look at the paper she cites:

      Increased contralateral suppression of otoacoustic emissions indicates a hyperresponsive medial olivocochlear system in humans with tinnitus and hyperacusis

      That's all!

      I must say I don't know what the hell this means, is it good is it bad? You tell me!

      (Seriously, I don't understand scientific papers).
       
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    4. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      Glad to see she is still producing real research for the good of our community... I just hope something comes from it.
       
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    5. lucy_snow

      lucy_snow Member

      Tinnitus Since:
      2018.03
      Cause of Tinnitus:
      hearing loss/ibuprofen
      Is this related to Dr. Shore's device?
       
    6. Kam75

      Kam75 Member

      Location:
      FRANCE
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced trauma in 2014 and 2019+ototoxic drug in 2020
      I haven't read the scientific paper, but I don't think so.

      I am also impatiently waiting for news about Shore's device, as I have no confidence in Lenire.
       
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    7. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      As I see it this is the soonest treatment that may be made available to us, maybe even available next year. How can there be no updates and tea leaf reading in this thread?
       
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    8. Kam75

      Kam75 Member

      Location:
      FRANCE
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced trauma in 2014 and 2019+ototoxic drug in 2020
      I wait every single day for news from Susan Shore's device but there is none :(
       
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    9. Sironketchup

      Sironketchup Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      SSHL / Stress
      This treatment is my gap filler of hope until Neuralink. I hope so much that Susan Shore is gonna make it. If not her then Elon.
       
    10. EDDTEKK

      EDDTEKK Member

      Location:
      Belgium
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Infection
      I also wonder why Dr. Shore's device takes so long! What the hell is the reason. There are people suffering so badly out there.
       
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    11. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      COVID-19 and good science I think. I know they shut down their clinical trials for a year when COVID-19 broke out and from reading her papers and listening to some of her talks she is a proper academic researcher doing proper academic research and these things are much more about doing a good job than a fast job.

      I wonder what the chances are of Tinnitus Talk Podcast interviewing her.
       
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    12. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      You know if something could just manage my symptoms, let’s say dial the tinnitus volume down by 50%, it would still be audible basically 24/7 but I think it would be low enough for me to ignore it. It doesn’t have to be perfect to make a massive difference in my quality of life.
       
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    13. Markku
      Inspired

      Markku Founder Staff Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      100%. ETA undefined, but it's coming. And beforehand, we'll give the community the chance to submit questions like for many of our earlier episodes. (y)

      Speaking of the Tinnitus Talk Podcast... I'm currently working on the Prof. Dirk De Ridder episode. It's coming for our Podcast Patrons as a video version later this month, with the public audio release following in early July. Content wise, it's been a blast to edit this one.

      If you guys have suggestions for future guests, please submit them here.

      dirk-de-ridder-podcast.png
       
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    14. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      If you get a choice of timing I wonder if it would be best to interview her after she has results to talk about.
       
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    15. F-u-T

      F-u-T Member Podcast Patron Benefactor

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      I wouldn’t wait. She may pass away before she has results to share!!!

      (Sorry. I couldn’t help myself.)
       
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    16. OptimusPrimed
      Spaced

      OptimusPrimed Member Benefactor

      Tinnitus Since:
      10/2007
      Cause of Tinnitus:
      Acoustic trauma
      If her research helps, her device is approved and helps those of us with subjective or somatic tinnitus I would wait another 10 years. A 50% reduction in tinnitus could be life changing for many. It doesn’t have to go away completely.
       
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    17. Orions Pain
      Sad

      Orions Pain Member Benefactor Hall of Fame

      Tinnitus Since:
      11/2019
      Cause of Tinnitus:
      A series of unfortunate events
      Knowing that there is something that would help me manage my tinnitus should it get even worse in the future for whatever reason would be major. It's bad as it is, but the idea of it worsening and not having anything to help is terrifying. Plus as you said, even a 50% reduction would be life changing. I can live with a little bit of tinnitus.
       
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    18. Oceanick
      Inspired

      Oceanick Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Antibiotics
      The winds of Tinnitus
      ~Susan R.R. Shore.
       
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    19. Pete88

      Pete88 Member

      Tinnitus Since:
      02/2018
      Cause of Tinnitus:
      Likely noise
      Completely agree. It's the idea of it getting worse that I worry about. If it was frozen or whatever so it never gets any worse, that would be good enough for me. Though of course, a reduction or elimination would be amazing.
       
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    20. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      I have the opposite reaction, I can’t imagine it becoming worse in any meaningful way so at least that is one thing I don’t have to worry about.

      That being said this is the one technology that is potentially close enough to reality that I tell myself that maybe in the next 2 years there is a chance that some meaningful decrease in my symptoms might be possible.
       
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    21. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Everyone here realizes Dr. Shore's device is only intended to work for people who have somatic tinnitus, correct?

      Please, if I’m wrong, let me know.
       
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    22. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      No, that’s just her trial criteria. She is unsure if it works for everyone but she does it’s the same fusiform cells, whether it’s from either ailment. The problem comes from the same place in the brain.
       
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    23. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      My real concern is about the limitations of the sound portion of the treatment. Not too unusual for a middle-aged person, my hearing at 14-16 kHz is ‘meh’ (technical term). If they need to match the audible stimulation to the pitch of ultra high pitch tinnitus I wonder what the hearing threshold would need to be for treatment.
       
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    24. Martin69
      Artistic

      Martin69 Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      10/2013
      Cause of Tinnitus:
      (Health) Anxiety
      Sorry being a downer here, but I have not much hope that Dr. Shore's device will be available soon.

      Neuromod published a product in much less time. OK, it is not really working. ;)

      But what is so difficult about getting Dr. Shore's device finished? They have been doing tests and trials forever. And no one even knows about any intermittent results?

      How many years do we still have to wait? Is that so complicated that it takes a decade to finish such a product?

      Just my thoughts... We all live in hope that the device will work. But is there any evidence? Please let me know.
       
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    25. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      I think right now the hope lies in the strong results from her first trial. Very convincing results with a 6 weeks treatment and 6 weeks sham with a a washout period in between. There were 2 groups, 1 got the placebo first, the other got the treatment first. In both groups real improvements including a decrease in volume and harshness only occurred with the treatment (10% of patients reported silence). The other piece that gives hope in her device is that she really knows what she is doing and trying to do with this treatment. I've read some of her papers and watched some of her lectures and it is so far above my head I really don't understand it, but she does.

      On the other hand her study had only 20 patients and she shut down her current study for an entire year due to COVID-19.

      It is worth reading the original paper, I just did the other day and it made me hopeful.
       
    26. Lukee

      Lukee Member Podcast Patron Benefactor Ambassador

      Location:
      Toronto, Canada
      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Wim Hof Breathing Exercises
      Dr. Shore's device has shown significant promise in early trials. The reason why Neuromod made it to market before UofM device is because one is for profit and the other is institutional. The mechanism by which they operate are different, not to mention the red tape. I know that it’s taking forever and a day but there is likely good reason for it beyond just the bureaucratic process.
       
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    27. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      This keeps on coming up but it seems to have more to do with Shore intentionally limiting scope than the odds of it working more broadly. Frankly, I just don't see the rationale for her feeling that neuromodulation would only work for somatic tinnitus.
       
    28. Ali.sy

      Ali.sy Member

      Location:
      Deutschland
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Headphones
      Can anyone share the link to the study? I want to know when the research will end and the results will be published.
       
    29. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Well, you should make her explain her rationale then.
       
    30. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      I can't find any paper detailing her ongoing study, just the one published in 2018. There is a fair bit of detail about her ongoing study on ClinicalTrials.gov.

      I think from prior discussions it is anticipated that this current study will be finishing up towards the end of this year and she has certainly made a number of public statements about wanting to move aggressively to marketing her device if the results are positive.

      I think aside from that it is a bit of a black hole at the moment.
       
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