New University of Michigan Tinnitus Discovery — Signal Timing

Discussion in 'Research News' started by Hudson, Jun 20, 2013.

    1. fade2black244
      Spaced

      fade2black244 Member Benefactor

      Tinnitus Since:
      03/2017
      Cause of Tinnitus:
      Noise Induced
      I mean, more research isn't such a bad thing. We all know how Lenire turned out. Even if she isn't able to make a decent commercialized product, at least she'll have the research and we'll have a greater understanding so that when someone does get close to making something worthwhile they won't make the same mistake. At this point, there's no reason not to let her do the research even if it will take potentially years.
       
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    2. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      Does anyone know if they use a standard audiogram or an extended for their device?
       
    3. Jack Straw
      Balanced

      Jack Straw Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Location:
      US
      Tinnitus Since:
      1990s
      Cause of Tinnitus:
      Infection, Acoustic Trauma
      Has there been any update from Dr. Shore regarding her research or device?
       
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    4. Isabella 123
      Curious

      Isabella 123 Member

      Location:
      Chapel Hill NC
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably traumatic noise event
      I read somewhere that their next clinical trial was delayed by COVID-19 but has now begun with report out in late fall.
       
    5. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Someone I know, who stays in touch with Dr. Shore, told me today that she is trying to commercialize her device before 2023.
       
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    6. Isabella 123
      Curious

      Isabella 123 Member

      Location:
      Chapel Hill NC
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably traumatic noise event
      Oh Deb, that is awesome news! Keep us updated please!
       
    7. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Screenshot_20210328-110138_Gmail.jpg
       
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    8. Isabella 123
      Curious

      Isabella 123 Member

      Location:
      Chapel Hill NC
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably traumatic noise event
      @DebInAustralia, I wonder if anyone has even a clue what they mean by commercialization? Clinics where we go for treatment? Devices for home use?

      I’m afraid they will be successful but so expensive I won’t be able to afford treatment/purchase so I will be no better off.
       
    9. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      I think they'll have to factor in people's budgets. I wouldn't worry about that.
       
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    10. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Sorry if this question is a bit "on the nose" but I don't know anything about this device.

      How is Dr. Shore's device different from Lenire'? Does it work, like, at all?
       
    11. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      Commercialization means that we will be able to purchase it. It means developing the production, supply chain, distribution, fitting and sale of the devices. I think this is opposed to its current status as an experimental device that you have to be part of the clinical trial to receive.

      I very much assume that this will be a home use product that will have to be set for your hearing/tinnitus at a clinic
       
    12. Isabella 123
      Curious

      Isabella 123 Member

      Location:
      Chapel Hill NC
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably traumatic noise event
      I’ve read in more than one place that the volunteers were all chosen because they have the ability to alter the sound of their tinnitus by putting pressure on their head or clenching their jaws.

      So I am assuming the device will only help those with that kind of tinnitus, which is not me. Another Fail.
       
    13. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      I wouldn't rule it out.

      Maybe you could ask Susan Shore if you would likely benefit from the device?
       
    14. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      And even those are probably not going to have much difference on their tinnitus; Lenire failed, why wouldn't this?
       
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    15. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
      Clown World
      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      You're better off waiting for regeneration medicine like FX-322, PIPE-505 and OTO-413. I really hope PIPE-505 results are positive. That would put it about the same timeline as FX-322 so we could get both.
       
    16. Isabella 123
      Curious

      Isabella 123 Member

      Location:
      Chapel Hill NC
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably traumatic noise event
      In Dr. Shore's clinical trials there was great success. Some people actually had their tinnitus go away completely and the others had much quieter tinnitus. They found that the effect was not permanent so I think there's going to be a small device you use at home maybe every day or maybe once a week. This is what I read today in an interview with Dr. Shore.
       
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    17. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      What kind of tinnitus did those people have? Can you share a link to the interview please?
       
    18. Isabella 123
      Curious

      Isabella 123 Member

      Location:
      Chapel Hill NC
      Tinnitus Since:
      12/2013
      Cause of Tinnitus:
      Probably traumatic noise event
      They are able to change their tinnitus sound by applying pressure to their heads or clenching their jaws. This is disconcerting to me as I certainly can’t do that! So now I’m wondering if this is going to be helpful!

      Here’s the link to that article:

      This Small Device Could Silence the Maddening Symptoms of Tinnitus
       
    19. Jimmyboi

      Jimmyboi Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      Dr. Shore's device theoretically is a more targeted application.

      Think instead of taking a painkiller this is applying it directly to the place it hurts.

      Worth waiting on Phase 3 results.
       
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    20. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      The sample size of her trials to date was very small, smaller than Neuromod's even. I wouldn't draw any conclusions about it yet. The Minnesota device seemed more promising, TBH, but now that project is dead.
       
    21. Mathew Gould

      Mathew Gould Member Benefactor

      Tinnitus Since:
      6/2017
      Cause of Tinnitus:
      Neck/Jaw misalignment
      My tinnitus is from neck and jaw issues. Before I got my TMJ splint, I had about 4-5 different sounds in different locations in my head. Now I only have 1 most of the time, but sometimes 2 sounds. I can never modulate my main sound, but if I yawn, turn my neck, etc I can modulate a second sound...

      I'm wondering if Dr. Shore's device would help me?
       
    22. Mathew Gould

      Mathew Gould Member Benefactor

      Tinnitus Since:
      6/2017
      Cause of Tinnitus:
      Neck/Jaw misalignment
      These Universities, especially one as big as Minnesota make tons of money. Too bad it got cancelled.
       
    23. Kam75

      Kam75 Member

      Location:
      FRANCE
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced trauma in 2014 and 2019+ototoxic drug in 2020
      After the failure of the FX-322 Phase 2a, my hopes are now focused on Susan Shore's device.

      But a question is bothering me; what do you think are the probabilities that this device causes trigeminal neuralgia?

      We know that Lenire can cause this terrible disease (one person on this forum contracted this disease only 6 days after using Lenire).

      This scares me a lot.

      Do you know if Susan Shore's device stimulates the same nerves as Lenire?
       
      • Good Question Good Question x 1
    24. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      What does the amount of money the universities make have to do with anything? Most of university research is the faculty being granted external funding by places like the national science foundation and many other funding repositories, and then the university actually *takes*, not gives, funds from the faculty to cover the expenses of their lab (overhead, utilities, janitorial services etc...). I was also under the impression until recently that universities directly funded research, but I have multiple friends who are doing PhDs and are Fullbright scholars, and they all tell me 95% of scientific grants come from funding outside the university itself (in the cases of the people I know - Cornell, Columbia, and Wisconsin-Madison).

      More to the point - we shouldn't dismiss or put stock in this device until we have data - the emo pessimists in this thread should put on black eye shadow and go listen to Green Day in the parking lot behind their local mall.
       
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    25. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I believe Dr. Shore's device does not stimulate the vagus nerve, though someone may correct me. It stimulates the cheek and neck rather than the tongue.
       
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    26. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      what-is-dead-may-never-die.gif
       
    27. VeryUnfortunate
      Stressed

      VeryUnfortunate Member Benefactor

      Tinnitus Since:
      January 2021
      Cause of Tinnitus:
      Acoustic Trauma
      Any more news on Dr. Shore's device?
       
      • Good Question Good Question x 1
    28. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Screenshot_20210417-183826_Samsung Internet.jpg
       
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    29. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Can't predict exact timeline should be the motto of the Shore device.
       
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    30. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      Susan CPETL Shore :). In all seriousness she's doing a lot of good work and I hope it benefits us.
       
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