Sound Pharmaceuticals (SPI-5557 & SPI-1005)

Not sure.

I have no clue how long we would have to take the drug.

 

Here are the very basics about the drug:

https://en.wikipedia.org/wiki/Ebselen

PubMed has more detailed physiologic and biochemical info (as well as studies on the compound).

 

Goddamn the wait is unbearable, the cures for noxacusis are sitting in a lab.

 

I know it sucks that we are suffering from this. I just really hope SPI-1005 helps with pain hyperacusis but if not we have FX-322. Please help us.

 

Thanks so much for the info!

 

The solutions just can't come soon enough. Hate to wish life away but if we all went to sleep tonight and woke up in 2025 I don't think too many of us would mind.

 

I never really followed this SPI-1005 thread... Can someone recap if it makes sense to try it for noise-induced tinnitus and what is the drug's potential mechanism on tinnitus?

 

They are recruiting for testing it on acute noise induced hearing loss now.

The mechanism is multi factorial but the most important is probably that it dampens Glutamate's neuroexcitability effects. It also is a potent free radical scavenger and inhibits mediators of oxidative stress as well as somewhat generally anti inflammatory. It also has vascular effects.

The Glutamate hyperexcitabilty effects are particularly interesting to me and a substantial part of tinnitus generation acutely and variably contributing chronically. I suspect it will have at least some effect on most people and a dramatic effect on some. But so far it has been shown to be safe and is a pill so it will be worth a try I think.

It has only been tested on Meniere's patients so far and did significantly lower their tinnitus but Meniere's has a significant inflammatory and vascular component.

Off hand, I could see people with fluctuating tinnitus benefiting more from this chronically but it may have potent ability to prevent spikes/worsenings.

 

Our main hope is that this can somehow help noxacusis.

 

Given COVID-19 I don't feel as though tinnitus is making me miss out on life. Maybe by next fall that's when tinnitus will become my biggest impediment again.

 

Is there any link/info on when the SPI-1005 clinical trials against COVID-19 are supposed to end/post results?

 

SPI-1005 Treatment in Moderate COVID-19 Patients

 

Thanks. So final data collection date is April 2021, and results may take however long it takes to compile them, I guess?

 

Yes, they should have all the data by this date.

 

So you can buy Ebselen (SPI-1005) online. That’s pretty interesting.

Does anyone know that dosage is used in the human trials?

 

400 mg twice per day.

 

There are two cohorts. One is 200 mg BID and one is 400 mg BID.

 

Do you think short to medium term administration of something with GABAergic effects could produce a similar outcome? I'm thinking, perhaps incorrectly, that it could help blunt the hyperexcitability having to do with Glutamate which you mentioned.

 

Hasn't been shown to so far. I suspect it is because you aren't really decreasing Glutamate or its effects in that case as much as decreasing the symptoms of it.

 

Does that mean if you do well on benzos, that’s a sign SPI-1005 could be beneficial to you?

 

I think ebselen’s full effects are poorly understood. Just like benzos. Anybody with ear issues should try it when they can, but it’s tough to say what it will do for anybody that doesn’t have Meniere’s.

 

I think its effects will be highly variable depending on how much is structural damage versus neuro inflammation in each individual. I don't at all expect it to be universally helpful except for certain etiologies.

 

Not necessarily imo.

 

That's it boys, I'm breaking into Sound Pharmaceuticals headquarters to get this drug.

 

Let me know how much cash you want to pick up extra and I’ll pay it. Jk... but seriously, though.

 

If Ebselen turns out to get rid of pain hyperacusis then thank God because this will be the first drug to help us.

I still think FX-322 will be the one to help us with pain hyperacusis but if it turns out it will be Ebselen then I hope we don’t have to take it long term.

 

I had a setback last night after doing quite well for a few weeks, just hope it's not a bad one.

I'd do anything to try this stuff right now.

 

My thoughts are that if Ebselen works then we’d take it until FX-322 was publicly released.

 

For Meniere's they completed a Phase 2 trial and also had tinnitus on their outcome measure list. Do they have released some info how this drug has affected tinnitus? I can only find a short summary on their website saying it has improved hearing.

 

I need this drug now. Meniere's is ruining my life