Sound Pharmaceuticals (SPI-5557 & SPI-1005)

Discussion in 'Research News' started by joe, Jan 26, 2012.

    1. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
      Hell
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      Not sure.
      I have no clue how long we would have to take the drug.
       
      • Like Like x 1
    2. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Here are the very basics about the drug:

      https://en.wikipedia.org/wiki/Ebselen

      PubMed has more detailed physiologic and biochemical info (as well as studies on the compound).
       
      • Informative Informative x 1
    3. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      Goddamn the wait is unbearable, the cures for noxacusis are sitting in a lab.
       
      • Agree Agree x 1
      • Optimistic Optimistic x 1
    4. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
      Hell
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      I know it sucks that we are suffering from this. I just really hope SPI-1005 helps with pain hyperacusis but if not we have FX-322. Please help us.
       
      • Agree Agree x 5
      • Optimistic Optimistic x 1
    5. twa
      Busy

      twa Member Benefactor

      Location:
      US
      Tinnitus Since:
      2017- mild /Sept. 2020-moderate
      Cause of Tinnitus:
      meds/acoustic trauma
      Thanks so much for the info!
       
    6. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      The solutions just can't come soon enough. Hate to wish life away but if we all went to sleep tonight and woke up in 2025 I don't think too many of us would mind.
       
      • Agree Agree x 11
    7. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      I never really followed this SPI-1005 thread... Can someone recap if it makes sense to try it for noise-induced tinnitus and what is the drug's potential mechanism on tinnitus?
       
      • Good Question Good Question x 1
    8. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      They are recruiting for testing it on acute noise induced hearing loss now.

      The mechanism is multi factorial but the most important is probably that it dampens Glutamate's neuroexcitability effects. It also is a potent free radical scavenger and inhibits mediators of oxidative stress as well as somewhat generally anti inflammatory. It also has vascular effects.

      The Glutamate hyperexcitabilty effects are particularly interesting to me and a substantial part of tinnitus generation acutely and variably contributing chronically. I suspect it will have at least some effect on most people and a dramatic effect on some. But so far it has been shown to be safe and is a pill so it will be worth a try I think.

      It has only been tested on Meniere's patients so far and did significantly lower their tinnitus but Meniere's has a significant inflammatory and vascular component.

      Off hand, I could see people with fluctuating tinnitus benefiting more from this chronically but it may have potent ability to prevent spikes/worsenings.
       
      • Informative Informative x 7
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    9. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      Our main hope is that this can somehow help noxacusis.
       
      • Agree Agree x 1
    10. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Given COVID-19 I don't feel as though tinnitus is making me miss out on life. Maybe by next fall that's when tinnitus will become my biggest impediment again.
       
      • Agree Agree x 4
      • Informative Informative x 1
    11. Philip83
      Jaded

      Philip83 Member Podcast Patron Benefactor

      Location:
      Sweden
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Moped (2001) Noise blast (2014) Club (2017) Snowboard (2018)
      Is there any link/info on when the SPI-1005 clinical trials against COVID-19 are supposed to end/post results?
       
    12. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      • Helpful Helpful x 1
      • Informative Informative x 1
    13. Philip83
      Jaded

      Philip83 Member Podcast Patron Benefactor

      Location:
      Sweden
      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Moped (2001) Noise blast (2014) Club (2017) Snowboard (2018)
      • Useful Useful x 1
    14. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Yes, they should have all the data by this date.
       
      • Like Like x 1
    15. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      So you can buy Ebselen (SPI-1005) online. That’s pretty interesting.

      Does anyone know that dosage is used in the human trials?
       
    16. Demigod

      Demigod Member

      Tinnitus Since:
      1/2019
      Cause of Tinnitus:
      Virus infection of inner ear
      400 mg twice per day.
       
      • Informative Informative x 2
    17. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      There are two cohorts. One is 200 mg BID and one is 400 mg BID.
       
    18. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      Do you think short to medium term administration of something with GABAergic effects could produce a similar outcome? I'm thinking, perhaps incorrectly, that it could help blunt the hyperexcitability having to do with Glutamate which you mentioned.
       
    19. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Hasn't been shown to so far. I suspect it is because you aren't really decreasing Glutamate or its effects in that case as much as decreasing the symptoms of it.
       
      • Informative Informative x 1
    20. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      Does that mean if you do well on benzos, that’s a sign SPI-1005 could be beneficial to you?
       
    21. Croaker
      Haunting

      Croaker Member

      Tinnitus Since:
      01/2019 T, 04/2020 H
      Cause of Tinnitus:
      Unknown
      I think ebselen’s full effects are poorly understood. Just like benzos. Anybody with ear issues should try it when they can, but it’s tough to say what it will do for anybody that doesn’t have Meniere’s.
       
    22. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I think its effects will be highly variable depending on how much is structural damage versus neuro inflammation in each individual. I don't at all expect it to be universally helpful except for certain etiologies.
       
    23. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Not necessarily imo.
       
    24. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      That's it boys, I'm breaking into Sound Pharmaceuticals headquarters to get this drug.
       
      • Like Like x 6
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      • Funny Funny x 1
    25. Marin
      Depressed

      Marin Member

      Tinnitus Since:
      6/18/2020
      Cause of Tinnitus:
      SSNHL... probably previous noise exposure, too
      Let me know how much cash you want to pick up extra and I’ll pay it. Jk... but seriously, though.
       
      • Like Like x 2
    26. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
      Hell
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Ear Infection
      If Ebselen turns out to get rid of pain hyperacusis then thank God because this will be the first drug to help us.

      I still think FX-322 will be the one to help us with pain hyperacusis but if it turns out it will be Ebselen then I hope we don’t have to take it long term.
       
      • Like Like x 5
    27. 100Hz

      100Hz Member Benefactor

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Noise exposure
      I had a setback last night after doing quite well for a few weeks, just hope it's not a bad one.

      I'd do anything to try this stuff right now.
       
      • Agree Agree x 3
      • Hug Hug x 2
    28. weab00
      Alone

      weab00 Member Benefactor

      Location:
      depression-ville
      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      noise, whiplash; 08/20 H
      My thoughts are that if Ebselen works then we’d take it until FX-322 was publicly released.
       
      • Agree Agree x 1
    29. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      For Meniere's they completed a Phase 2 trial and also had tinnitus on their outcome measure list. Do they have released some info how this drug has affected tinnitus? I can only find a short summary on their website saying it has improved hearing.
       
      • Good Question Good Question x 1
    30. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      Gunfire (Maybe) & Menieres
      I need this drug now. Meniere's is ruining my life :(
       
      • Hug Hug x 5

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