Sound Pharmaceuticals (SPI-5557 & SPI-1005)

Discussion in 'Research News' started by joe, Jan 26, 2012.

    1. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      FX-322 just broke my heart, but I'm already in love again. I have to give myself time and resist the urge to get into a new hearing drug relationship too soon off the rebound.
       
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    2. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      Ebselen is probably the only clinical stage drug I'm still keeping my eyes on.
       
    3. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      I would add OTO-413 to the list.
       
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    4. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      There's a number of promising drugs in the pipeline. I think the issue is timeline. Within 20 years, there will probably be quite a few major QoL improvers.
       
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    5. spacehunter

      spacehunter Member Benefactor

      Tinnitus Since:
      10/2019 (mild), 09/2020 (severe)
      Cause of Tinnitus:
      SSHL
      FX-322 was great as it had the promise to cure the problem at (one of) its roots and also because it was being developed rapidly.

      After the disaster with FX-322, we should lower our expectations.

      SPI-1005 will at most alleviate our problems, but not cure them. The beauty of SPI-1005, on the other hand, is that one can immediately try it out...
       
    6. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      I don't disagree, but I'm not going to invest my emotional health in a drug that won't be available for another one to two decades.
       
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    7. Emgee

      Emgee Member Podcast Patron Benefactor

      Location:
      United States
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      Cause of Tinnitus:
      Modern Society = Too Loud
      I got maybe two years in me. Maybe. For me, it’s either some improvement via Ebselen or game over.
       
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    8. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
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      Do we know when Phase 3 will be completed?
       
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    9. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      I think Phase 3 has not even started, it’s premature to say about completion date.
       
    10. spacehunter

      spacehunter Member Benefactor

      Tinnitus Since:
      10/2019 (mild), 09/2020 (severe)
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      As far as I know it has not even started yet. According to this website it will probably be completed in April 2023...
       
    11. Jrblovsky

      Jrblovsky Member

      Location:
      USA
      Tinnitus Since:
      Christmas 2019
      Cause of Tinnitus:
      NOISE/Menieres Who knows
      As a guy who actually attempted to commit suicide and failed, I would not recommend it. I suffer as bad as anyone here and it's not worth it. Figure out a way to deal with it.
       
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    12. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      tinnitus-sufferer-fx-322-ebselen.jpg
       
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    13. Gee82

      Gee82 Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Noise
    14. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      Sorry all, another refugee from the FX-322 thread here...

      Having worked that thread for over year and jumping ship to skim read the last few pages here... It seems that this drug has had good results and is even oral!

      In my mind this is even better than an injection because... No injection.

      I recall a concern with FX-322 was EHF / penetration. Do we have indication that this drug acts across all frequencies?
       
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    15. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I think it should act on all frequencies. The drug gets really good systemic penetrance. Crosses both the BBB and Blood/Cochlear barrier well. I don't think everyone will likely get the same benefit from it since I think it will depend on a lot of individual inflammatory factors. That's just my suspicion. Would be great if it did work for everyone.

      I think it holds great promise in preventing spikes and new/further damage for pretty much everyone, though.
       
    16. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      I have devoured so many of your posts that it feels like conversing with a celebrity!

      I am an engineer, not a scientist, but digested the 2009 paper on the development of Ebselen. I can't find the 2021 February paper using my sources.

      The 2009 paper suggests, like you did, that the primary thrust is prevention, not cure. Has the emphasis on cure increased since that point, or is it wishful thinking on my part?
       
    17. Kam75

      Kam75 Member

      Location:
      FRANCE
      Tinnitus Since:
      2014
      Cause of Tinnitus:
      Noise induced trauma in 2014 and 2019+ototoxic drug in 2020
      Sorry if this is a dumb question, but I'm also a refugee from the FX-322 thread here.

      What exactly is SPI-1005? According to what I have read, it is a treatment for COVID-19, currently in Phase II or III clinical trials.

      How come this drug can help tinnitus?
       
    18. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I think it will be pretty universally effective as a preventative but as far as treating tinnitus, I think it will have some benefit in most people but a dramatic benefit in a certain segment.

      You aren't fixing an underlying cause, you are attenuating the after effects.

      However, I think people with severe tinnitus might especially benefit in breaking the stress-glutamate and dynorphin release--tinnitus--further stress, perpetuating worse tinnitus cycle. So they could possibly benefit the most.

      This is just my take and I would love to hear other opinions.
       
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    19. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      So it should put us at a spikeless baseline? In theory.
       
    20. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
    21. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      It has a lot of effects. That seems to be something the drug could be capable of for sure.
       
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    22. annV
      Fine

      annV Member Benefactor

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      unknown - possibly hereditary
      Here's the full February 2021 paper.
       

      Attached Files:

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    23. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Oh that's awesome, my spikeless baseline is great, I feel completely comfortable with it.
       
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    24. tarmaced
      Wtf

      tarmaced Member

      Tinnitus Since:
      2004 (mild) 2018 (not so mild)
      Cause of Tinnitus:
      Ear infections, compounded by noise exposure
      I am the opposite, I never have spikes, just changes in attitude when it gets too much to bear...

      I guess this means that I am in the pool of people it probably won't work for :(
       
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    25. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Well, this drug is extremely complex so I'm mostly speculating but if yours is severe enough to be "too much to bear" at times I think you likely have more of a locally inflammatory component than you might otherwise. Just my opinion.
       
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    26. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Location:
      Mexico
      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      NIHL
      Hey who knows really, it could work wonders for you and do nothing for me. Don't knock it till you try it!
       
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    27. Gee82

      Gee82 Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Noise
      No, originally the trial was supposed to end in April 2021.
       
    28. Keith Handy
      Worried

      Keith Handy Member

      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      Stress + sleep deprivation + noise
      You and me both.

      Still want "the goop" too, though.
       
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    29. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

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      Damn, I thought they were going to start Phase 3 but the ClinicalTrials.gov website states Phase 2.
       
    30. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Phase 3 for Meniere's (ends 2023).
      Phase 2 for COVID-19 (ends 2022).
       
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