Vitamin Supplement (Nicotinamide Riboside) Successfully Prevents Noise-Induced Hearing Loss

[FGG]

I have now seen this article:

https://www.news-medical.net/health/Do-NAD-Boosters-Help-You-to-Live-Longer.aspx

"Although NAD boosters are claimed to be safe for humans, it has been found that repeated intake of it can increase the total cholesterol and low-density lipoprotein (LDL)-cholesterol levels in the blood. Moreover, studies have indicated that increased expression of NAMPT (a major NAD+-producing enzyme) is associated with an increased risk of developing potentially fatal brain tumors (glioblastoma). NAMPT promotes rapid tumor growth by increasing the release of inflammatory and oncogenic molecules."

What do you think? (and @Chinmoku)

I read at least her first reference and it actually concludes that it lowers glioblastoma risk.

The key phrase is "wild type mice"' the last reference said mice engineered to get cancer are more susceptible when given NAD+ because of its pro-angiogenic effects presumably.

This goes back to testing your genome I suppose, which everyone should probably do anyway (as with the MTHFR example).

 

[all to gain]

I read at least her first reference and it actually concludes that it lowers glioblastoma risk.

The key phrase is "wild type mice"' the last reference said mice engineered to get cancer are more susceptible when given NAD+ because of its pro-angiogenic effects presumably.

This goes back to testing your genome I suppose, which everyone should probably do anyway (as with the MTHFR example).

So would you recommend laying off of NR and other NAD+ precursors until one's genome is known?

What exact test would I need to do, i.e. what's it called?

 

[FGG]

So would you recommend laying off of NR and other NAD+ precursors until one's genome is known?

What exact test would I need to do, i.e. what's it called?

If you get 23andMe done, you can then upload your genome to Promethease and look for things like MTHFR.

As far as cancer risk, I don't know what specific cancer genes those rats were breed to have or how relevant they would be in people. The nice thing about Promethease is they highlight most of your "bad" genes for you.

For instance, I have Factor V Leiden and a much, much higher risk of Lymphoma. Both of those were highlighted for me. On the plus side, i am among the lowest risk for Alzheimer's so it wasn't all bad news.

If you are a worrier, it will tell you bad genes you didn't know about, fair warning.

 

[all to gain]

If you get 23andMe done, you can then upload your genome to Promethease and look for things like MTHFR.

As far as cancer risk, I don't know what specific cancer genes those rats were breed to have or how relevant they would be in people. The nice thing about Promethease is they highlight most of your "bad" genes for you.

For instance, I have Factor VI Leiden and a much, much higher risk of Lymphoma. Both of those were highlighted for me. On the plus side, i am among the lowest risk for Alzheimer's so it wasn't all bad news.

If you are a worrier, it will tell you bad genes you didn't know about, fair warning.

OK.

For now I'm just going to keep taking the NR until I get a test. I'm only taking a low dose anyway.

 

[AnxiouslyWaiting]

OK.

For now I'm just going to keep taking the NR until I get a test. I'm only taking a low dose anyway.

Have you got back to the near silence you got on the 300-400mg dose you were on or are you still working your way up?

 

[all to gain]

Have you got back to the near silence you got on the 300-400mg dose you were on or are you still working your way up?

I've not been taking it regularly lately. I only have a little left, and I have to get it shipped in.

I'm not sure what to do now to be honest. I'm not 100% sure if my near silence was due to upping the dose to 300-400 mg or not, and I was only on that dose for a day or two. I did get headaches though, hence I dropped down.

 

[AnxiouslyWaiting]

I've not been taking it regularly lately. I only have a little left, and I have to get it shipped in.

I'm not sure what to do now to be honest. I'm not 100% sure if my near silence was due to upping the dose to 300-400 mg or not, and I was only on that dose for a day or two. I did get headaches though, hence I dropped down.

Yeah it would have been interesting to see if it had the same effect again. It sucks that the benefits disappeared after you stopped (if the NR was the reason and not just a coincidence).

I would definitely prefer whatever cures us not to be something we have to take every day.

 

[Lane]

FWIW

The Potential Role of the Mitochondria and Nicotinamide Riboside in Addressing COVID-19

 

[all to gain]

I read at least her first reference and it actually concludes that it lowers glioblastoma risk.

The key phrase is "wild type mice"' the last reference said mice engineered to get cancer are more susceptible when given NAD+ because of its pro-angiogenic effects presumably.

This goes back to testing your genome I suppose, which everyone should probably do anyway (as with the MTHFR example).

I presume this is what you mean by pro-angiogenic effects?:

"Because cancer cells utilize increased glycolysis, and because NAD enhances glycolysis, Nampt is often amplified in cancer cells."

 

[all to gain]

I read at least her first reference and it actually concludes that it lowers glioblastoma risk.

The key phrase is "wild type mice"' the last reference said mice engineered to get cancer are more susceptible when given NAD+ because of its pro-angiogenic effects presumably.

This goes back to testing your genome I suppose, which everyone should probably do anyway (as with the MTHFR example).

Here's another interesting article: https://www.scientificamerican.com/...unknowns-about-popular-antiaging-supplements/

 

[FGG]

Here's another interesting article: https://www.scientificamerican.com/...unknowns-about-popular-antiaging-supplements/

That was the third reference from from your first link. And the blogger took her info from that mentioned mice genetically engineered to get pancreatic cancer got more cancer from taking NAD+ (and others got less liver cancer).

 

[FGG]

I presume this is what you mean by pro-angiogenic effects?:

"Because cancer cells utilize increased glycolysis, and because NAD enhances glycolysis, Nampt is often amplified in cancer cells."

No, that's separate. But it's all really like saying "because cancer cells need energy if you give them more energy they grow faster. "

So, overall, if you happen to get cancer cells they will grow faster because of increased blood flow and energy utilization. But you first have to get the cancer (hence why they used pre-disposed rats).

 

[all to gain]

No, that's separate. But it's all really like saying "because cancer cells need energy if you give them more energy they grow faster. "

So, overall, if you happen to get cancer cells they will grow faster because of increased blood flow and energy utilization. But you first have to get the cancer (hence why they used pre-disposed rats).

OK, got you.

But as in the "US, 1 in 2 women and 1 in 3 men will develop cancer in their lifetime", and what with a lot of cancer not being caught early on, wouldn't it be a big risk to take NAD precursors like NR?

 

[FGG]

OK, got you.

But as in the "US, 1 in 2 women and 1 in 3 men will develop cancer in their lifetime", and what with a lot of cancer not being caught early on, wouldn't it be a big risk to take NAD precursors like NR?

If you are in the more likely age bracket and/or have familiar history maybe the elevated risk of a faster growing cancer is something to consider. Not sure.

 

[Thuan]

So for those who have taken this incredibly expensive supplement for months, have you seen any positive effects?

 

[FGG]

So for those who have taken this incredibly expensive supplement for months, have you seen any positive effects?

It brought my tinnitus down a few notches but then plateaued to where it is now (6/10). I took this fairly early on so I can't be absolutely sure it wasn't just time.

It seems like @all to gain had some improvements over a longer time frame but had side effects so stopped.

 

[all to gain]

It brought my tinnitus down a few notches but then plateaued to where it is now (6/10). I took this fairly early on so I can't be absolutely sure it wasn't just time.

It seems like @all to gain had some improvements over a longer time frame but had side effects so stopped.

I can't 100% put it down to NR, that's the problem. But one day I woke up really having to look for my tinnitus, and my tinnitus was/is pretty bad.

I stopped as at a higher dose I got headaches, and then I read about the cancer thing I mentioned above. I may take it on and off, i.e. say 2 months on 2 months off. Would that do anything or is it something that needs to be taken continuously?

So, 23andMe was worth it? Did you find out about your ancestry?

 

[FGG]

I can't 100% put it down to NR, that's the problem. But one day I woke up really having to look for my tinnitus, and my tinnitus was/is pretty bad.

I stopped as at a higher dose I got headaches, and then I read about the cancer thing I mentioned above. I may take it on and off, i.e. say 2 months on 2 months off. Would that do anything or is it something that needs to be taken continuously?

So, 23andMe was worth it? Did you find out about your ancestry?

I did but I didn't really care about the ancestry stuff too much (some of it was surprising though).

Some of the genes from promethease give you an idea too (e.g. Factor V Leiden is only in people who have some British descent for instance).

It was definitely worth it for me because it told me why I can't metabolize certain drugs well (CYP2D6 poor metabolizer).

I don't think it's worth it unless you put it through promethease and you have specific concerns (e.g. cancer risks) or are wondering about drug metabolism. Here is what I came up with doing a quick search for genes implicated in glioblastoma risk:

Cyclin D1, CDK1, CDK2 RTK, PI3K.

So you would search for those genes on promethease if that was your worry.

 

[all to gain]

I did but I didn't really care about the ancestry stuff too much (some of it was surprising though).

Some of the genes from promethease give you an idea too (e.g. Factor V Leiden is only in people who have some British descent for instance).

It was definitely worth it for me because it told me why I can't metabolize certain drugs well (CYP2D6 poor metabolizer).

I don't think it's worth it unless you put it through promethease and you have specific concerns (e.g. cancer risks) or are wondering about drug metabolism. Here is what I came up with doing a quick search for genes implicated in glioblastoma risk:

Cyclin D1, CDK1, CDK2 RTK, PI3K.

So you would search for those genes on promethease if that was your worry.

I don't really have any specific worries as such, but you never know what might turn up by doing the test.

I will have to mull it over. Can't do it here anyway, so would have to wait until I went back to the UK or take a local analog of the test.

 

[Bambam0]

@Heinrich_S7 How are you doing with this? Would you still recommend it?

 

[Ben Winders]

Jumped on the mini hype train: coming out of the gates strong - started today with 600mg TruNiagen NAD+ (taking 2 pills of 300mg each) and 500mg Resveratrol.

This is the stack that I got:

Tru Niagen NAD+:
https://www.amazon.com/dp/B07TK4VYWS/
Resveratrol:
https://www.amazon.de/dp/B084WVT2J6/

 

[NewLionel]

So has NAD actually worked for a few people?

 

[all to gain]

So has NAD actually worked for a few people?

I'm unsure in my case.

I did seem to get some near silence one day as soon as I upped the dose from 200 mg to 400 mg, but I got headaches so stopped.

Then, just yesterday I started up again, taking 100 mg, but I added Astaxanthin 12 mg, and last night and much of today my tinnitus has been less intense. However, the Astaxanthin brought with it an upset stomach (although that could be to do with my diet being bad the last few days and taking in too much fibre) and bright red stool.

I am going to experiment a little with Astaxanthin at lower doses (maybe 2-4 mg), and also with NR in the 100-300 mg range and try different combinations of the two together.

Lots of caveats.

 

[FGG]

However, the Astaxanthin brought with it an upset stomach (although that could be to do with my diet being bad the last few days and taking in too much fibre) and bright red stool.

Astaxanthin is what makes flamingos pink. It changes everyone's stool to red just in case you were concerned.

 

[all to gain]

Astaxanthin is what makes flamingos pink. It changes everyone's stool to red just in case you were concerned.

Yeah, I know, I remember you saying LOL it was really red...

I must say, although it could be a big coincidence, that for much of the day I've found it harder to click my ears, and my mood seems to be better. Had a very good day overall. I need to find the right dose and persevere with it to see if I can get some long-time benefits from it.

 

[Zaccq]

I must say, although it could be a big coincidence, that for much of the day I've found it harder to click my ears, and my mood seems to be better.

I am experiencing a similar thing regarding "ear clicking". I had my ears cleaned and then had an ear infection 6 months ago and took antibiotic ear drops.

Afterward, I found there is a clicking noise in my ears when I blew my noise. I also had sore sides of my throat and sore ears. I didn't notice tinnitus badly until a month ago when it spiked.

This clicking noise has been improving recently, as has the tinnitus.

I found a good audiologist who did a high frequency hearing test (to 14khz) and reported they did not see any indication of SSHL or any clinical hearing loss. As I thought it might be due to medication, at the time.

Now, I wonder if there's inflammation of the inner ear by something else, that then causes tinnitus.

 

[DebInAustralia]

I had a day of almost total silence yesterday (nice xmas bonus) the day before I went up to 2x1 100mg one morning one at night. But this may just be a coincidence but I have a bad vertigo attack this morning. I have not read this can be a side effect. I will keep you updated.

I know this is an older post, but did you continue with Nicotinamide Riboside?

 

[DebInAustralia]

I've been taking the recommended doses of NR or NMN (a related compound, also a NAD precursor) for about a year and a half. I had slight hearing loss in both ears (10 dB or so) and complete loss of a small range of frequencies in my right ear due to a car backfiring right next to me. I'm now able to hear those frequencies again, and I estimate that my hearing is maybe 75-80% back to normal.

I think that the NR/NMN are finally starting to have a positive effect on my tinnitus. I've seen a number of people say that NMN actually made their tinnitus louder. It did that for me as well but not enough to make me stop taking it. However, in the last month I've started to have short periods of complete silence, and that's new. So I'm cautiously optimistic that my brain is finally figuring out that it doesn't need to keep making all that noise.

This is great news!

Has this continued to be the case?

I made a post earlier, unaware that your tinnitus had improved.

 

[DebInAustralia]

You're not going to notice drastic changes in 2.5 months. You have to stay on NAD+ for years to reap the benefits.

This isn't something you can take for a few weeks and have your hearing completely restored. It takes a long time. Like I said, I didn't even notice improvements for about 2 months. I still have it, but it's not nearly as bad as it used to be. And it seems to be getting *slowly* better as the months progress.

Since then it's improved quite a bit.

May I ask which Nicotinamide Riboside product are you using, and dose etc?

 

[DebInAustralia]

Thought I would mention that I'd been taking NR (and Pterostilbene) for a good two years before I experienced sudden hearing loss and tinnitus, via Elysium's Basis supplement, which I haven't seen mentioned in this thread surprisingly. Not that I've read every single comment. The hearing loss/tinnitus arrived this spring, about a month after recovering from walking pneumonia though I'm told a link cannot be 100% established.

I'd certainly like to think that the NAD+ precursor NR will slowly help me recover, at least somewhat, from these conditions, but during this period of course it hasn't.

Were you given Azithromycin, for the walking pneumonia?