Episode 20: The Man Who Donated a Million Dollars to Tinnitus Research

Discussion in 'Podcast' started by Tinnitus Talk, May 22, 2022.

    1. star-affinity

      star-affinity Member Podcast Patron Benefactor

      Tinnitus Since:
      1993, increase in 2020, then new in 2021
      Cause of Tinnitus:
      Unsure about the first. Too many beers? Music during sleep.
      Through half of the podcast I heard Dr. Hamid Djalilian say that sometimes the hair cell is intact, but the nerve endings have disconnected to the hair call.

      Here's a question being answered about if it's enough to regenerate hair cells to get hearing back, and if other things such as the nerve cells also have to be fixed:

      Hearing Health Hour Webinar | The Present and Future of Inner Ear Hair Cell Regeneration

      Hearing Health Hour Webinar | The Present and...

      Lisa Goodrich who's lab mostly focuses on the auditory nerve:

      ”…we have thought a long time about how the hair cells are innervated by the spiral ganglion neurons.”

      ”In a mouse where you can create a hair cell where their not supposed to be the spiral ganglion neurons will follow and they are pretty good at sorting out and trying to find a target to innervate”.

      Would be interesting to know what the take is on intact hair cells that have lost their nerves – why doesn't these nerves connect back to the hair cell if a newly created hair cell makes them connect?
    2. addot

      addot Member

      Tinnitus Since:
      Jan 2013
      Cause of Tinnitus:
      Noise exposure
      Mammals lack the ability to regenerate synapses in the inner ear. It's just something we can't do. However, some studies have shown that applying a chemical called brain-derived neurotrophic factor (BDNF) leads to synapse repair. This is the idea behind OTO-413, which is in clinical trials right now.

      As an aside, I came across a optimistic slide on that presentation you linked:

    3. hopes

      hopes Member

      Tinnitus Since:
      Cause of Tinnitus:
      I haven't heard the podcast yet but I have read the comments.

      And this "4 years" timeframe is unclear to me.

      4 years before their device is available to public or 4 years before they start human trials?
    4. hopes

      hopes Member

      Tinnitus Since:
      Cause of Tinnitus:
      Okay, I just listened to it so it is actually 4 years before they start to try it with humans in a clinical trial. Probably you'll need to double this time to get the human trials done and make it accessible to public if it's working.

      Well, that's a very long time waiting but at least they are trying.

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