MemberThis is a particularly good find as the FDA has begun their review of the New Drug Application for AXS-05.
Axsome Therapeutics Announces FDA Acceptance and Priority Review of New Drug Application for AXS-05 for Treatment of Major Depressive Disorder
Ketamine Relieves Depression by Restoring Brain Connections
- Thread starter Nic B
- Start date
Axsome Therapeutics Announces FDA Acceptance and Priority Review of New Drug Application for AXS-05 for Treatment of Major Depressive Disorder
- Feb 11, 2019
- 801
- Tinnitus Since
- 01/2014
- Cause of Tinnitus
- Headcold/Flu
Awhile ago I called my Primary Care Physician and requested a recommendation for a psychiatrist; I was notified that this COVID-19 shutdown engendered so many stress/depression related conditions (fear of contracting the virus, financial insecurity, enforced idleness and isolation that activated the level of paranoia exhibited in Munch's "The Scream") that I might well have to wait six months for an appointment.
This was in fact corroborated by the comment in last month's Esquire Magazine that this and last year's sales of alcohol nationally have increased by 24%.
But I'm with GBB; I am henceforth determined to try everything I can get.
After all, it would not be unusual for one of these new drugs for depression by sheer serendipity to also remedy tinnitus.
Recall that Depakote was originally developed for Epilepsy but was also found to be beneficial for migraines; Viagra was originally intended as a heart medication.
This was in fact corroborated by the comment in last month's Esquire Magazine that this and last year's sales of alcohol nationally have increased by 24%.
But I'm with GBB; I am henceforth determined to try everything I can get.
After all, it would not be unusual for one of these new drugs for depression by sheer serendipity to also remedy tinnitus.
Recall that Depakote was originally developed for Epilepsy but was also found to be beneficial for migraines; Viagra was originally intended as a heart medication.
Their website lists Ketamine as a related compound and Ketamime is available now:
https://axsome.com/axs-pipeline/about-axs-05/
Systemic NMDA antagonists work really well for some people but chronically especially there are risks.
There are a lot of NMDA Receptor Antagonists in the market. I don't see the first one to help tinnitus.
- Oct 31, 2020
- 1,383
- Tinnitus Since
- 9-17-2020
- Cause of Tinnitus
- turning everything up to 11
Yeah. Some people use Ketamine successfully that way and don't overdo it. Doesn't work for everyone but works very well for some people.
Mind sharing the name of the Santa Monica clinic? That's where I live and was considering this option as well.
Whatever helps lol.
I'm actually much more hopeful on ebselen like most, but this one is going to be available imminently.
- Oct 31, 2020
- 1,383
- Tinnitus Since
- 9-17-2020
- Cause of Tinnitus
- turning everything up to 11
I don't remember the name, so googled "Santa Monica Ketamine infusion" and found 3 or 4 different places right in the first page of the SERPs.
Looks like they are all around the Brentwood/Westwood/Marina Del Rey areas.
Sentinel
Member
- Apr 6, 2021
- 96
- Tinnitus Since
- Late November/Early December 2020
- Cause of Tinnitus
- Really epic hobbies
Question is can I get my dickhead "just put on a fan" doctor to let me take it despite only being depressed because of the sound in my ear/head.
I'm sure there's no data on if it helps tinnitus, but given the drug profile hopefully it does.
Even if he wanted to, I don't think he could prescribe it to you. It's a very potent antidepressant, you most likely need to be diagnosed by a psychiatrist.
I think out of any doctor the one easiest to trick would be a psychiatrist. IMO
Thanks for the laugh! You should find a new doctor.
But for the Ketamine, you'd need to talk to a psychiatrist and see if it's a fit. I doubt they'd prescribe it to you for just tinnitus, but if you have long term depression it might help.
I just wanted to loop back and say when I lower my Keppra dosage, it seems like night and day now, so it has provided some benefit. The more chaotic tinnitus seems to stabilize into continuous noise which is far preferable in my opinion. It goes from sounding like I'm on a battlefield to more of a varied but much more stable shhhhhhhhhhh.
Now I have to point out my tinnitus is very weird. I am one of (not trying to make myself sound special) the only people I have seen that literally has cycling noise, whereby sets of noise are mutually exclusive. I still don't really know what triggers that. So YMMV.
- Oct 31, 2020
- 1,383
- Tinnitus Since
- 9-17-2020
- Cause of Tinnitus
- turning everything up to 11
I just told my neurologist I wanted to try it and I had done a lot of research on experiences of people in the community, so she said okay it's very safe just watch out for rage feelings - if those happen you need to get off of it.
No prior conditions. It seems to change my pre-existing visual snow a bit but so far seems worth it as it stops a lot of the chaos of tinnitus - without it it's like a battlefield of random noises which are truly overwhelming - with it it's a more steady tone and less reactive - I still can't shower without earplugs but it helps me cope with the air conditioning running all summer and other noise by making the tone more "inert" and non-responsive to external sounds. It honestly gives me a huge amount of sanity back though every day is still tough.
- Oct 31, 2020
- 1,383
- Tinnitus Since
- 9-17-2020
- Cause of Tinnitus
- turning everything up to 11
- Jan 18, 2021
- 782
- Tinnitus Since
- 01/2021
- Cause of Tinnitus
- Wim Hof Breathing Exercises
My tinnitus faded away after using another psychedelic, Psilocybin.
I bet that Ketamine would have a similar effect, but you would probably have to do the inpatient loading dose that they do for chronic pain patients. I doubt that the little doses they do for depression would have much of an impact.
Ketamine infusions are pricey, especially the inpatient treatment.
I take Psilocybin instead, it's pretty much free. I have hemicrania continua, a condition that causes 24/7 migraine like symptoms. Tinnitus was one of the features.
I bet that Ketamine would have a similar effect, but you would probably have to do the inpatient loading dose that they do for chronic pain patients. I doubt that the little doses they do for depression would have much of an impact.
Ketamine infusions are pricey, especially the inpatient treatment.
I take Psilocybin instead, it's pretty much free. I have hemicrania continua, a condition that causes 24/7 migraine like symptoms. Tinnitus was one of the features.
I have done the inpatient Ketamine procedure 5 times. It does nothing for tinnitus. Sure wish it did...
Wow, what were you having it done for if you don't mind me asking? Do you have a pain condition like CRPS?
