Medical Advancements

My reply here is a bit belated but yes you're right - all the Nav 1.7 drugs are in pre-clinical development - I think Navega intends to start clinical trials in a year or two, however, which could expand the scope for compassionate use etc.

From what I have read, lack of specificity was one of the initial hurdles and there's definitely been progress on this but I think Xenon and Navega are companies to keep an eye on.

 

Very interesting. Here in Norway they are testing it for dementia. Especially on the type of dementia Robin Williams took his life over.

The pharmacy world is crazy hah... A med to dissolve mucus is suddenly now trialed for fibromyalgia and dementia. So why not noxacusis?

I'll have to have a long chat with my doctor.

You told me yesterday about Sound Pharmaceuticals. There was a guy on Facebook that had his doctor send an inquiry of compassionate use. Very interesting to hear their reply.

Thank you @FGG and your investigative mind.

 

Please follow up and let us know what Sound Pharmaceuticals says to them. I think a lot of people on this site would be very interested (myself included)...

 

I told him to come on here and tell us on the SPI-1005 thread

If not, I will.
He thought it could take a while though.

 

Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling

 

Breakthrough neurotechnology for treating paralysis

A bit of an older thing, but I really like the man's smile. This is how we will smile once our problems are fixed.

 

@FGG, have you tried Ambroxol yet?

 

I actually just got it today. I'm going to try 4x daily antivirals first (posted my reasoning for this in the hyperacusis section) for a few weeks first though, so I'm not throwing too many variables at it.

 

@Orions Pain should not be left out of this unfortunate roster, if it is not too presumptuous for me to speak on their behalf.

 

@FGG, maybe I have missed it in the jungle of different threads, but I'm curious if Ambroxol has helped your pain in any way? Thanks.

 

So far, 3 people including me have tried it and it seems to be that it makes a big difference for trigeminal/facial nerve pain and not so much on pain within the ear itself. It helps clear the ET as well. Is your pain more ear or face?

You can read the accounts in the "Pain Hyperacusis in Relation to Acoustic Shock & Synapse Disconnection" thread in the Hyperacusis section.

 

Definitely ear. No facial pain.

I have chronic kind of straining pain in my ears (could be MEM, but I have cut right Tensor Tympani muscle).

It could be the stapedius muscle. Is that not also the muscle that connects to the facial nerves?

My main problem is the mixture of distortion/UHF reactiveness to sound. So my pain lies in the UHF reactiveness in addition to a pain response as well. I'm not unsure anymore about what's wrong in my case. I can literally feel it stems from nociceptive NF in my cochlea. Am I alone in perceiving it like this? Why are all our cases so different?

Happy some of you got at least partial relief.

I'll see a pain doctor in two weeks. She likes to fill up with Lidocaine deep into my nostrils (transnasal ganglion blockade) which may have an effect, but very short of duration, indeed.

I'll definitely ask her about Ambroxol. It's supposed to be 40 times as potent as Lidocaine.

l'll read the appropriate thread. Thanks again FGG.

 

Fascinating work being done by Michael Levin and his lab on bioelectricity and its potential for regenerative medicine.

The New Yorker: Persuading the Body to Regenerate Its Limbs

Welcome to the Levin lab: investigating information storage and processing in biological systems

 

DeepMind says it will release the structure of every protein known to science

DeepMind will release the structures of all known proteins. I wonder if this will help us!

 

Paralysed man with severed spine walks thanks to implant



And the scientific article for those interested:

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

 

Small molecule lends big hope for brutal seizure disorder - Scope (stanford.edu)

All brain function is roughly based on a sort of balancing act between excitatory neurons, which fire in response to stimulus or during cell-to-cell communication, and inhibitory neurons, which keep the excitatory neurons in check, ensuring that they don't fire too much. The parvalbumin brain cells are essential to maintaining the inhibition side of the brain's activity.

Sounds familiar!