Prof. Thanos Tzounopoulos Receives $2 Million Grant

I do not understand how they can tell when the animal has or does not have tinnitus when it is something that is still difficult to verify in humans, knowing that animals do not speak!

 

My understanding is that the typical approach is to make a sound set at a specific volume level for which animals without tinnitus can hear the sound, and it causes a startle response. For animals with tinnitus, they do not hear the same sound (on account of the tinnitus) and it does not cause a startle response.

 

Basically: rat hears a sound -> gets food.

Repeat multiple times.

Rat goes for food when it hears a sound.

Induce tinnitus.

Rat goes for food without external stimulus -> rat has tinnitus.
Rat doesn't go for food without external stimulus -> rat has no tinnitus.

Tadaaa.

 

I have high hopes for this. Anyone have any new news on this by any chance?

 

Unfortunately not, since we saw a publication last month I imagine it'll be slow going until some clinical trials are hopefully announced.

However if you check Professor Tzounopoulos' publications this year already, he is a busy one.

https://scholar.google.com/scholar?as_ylo=2021&q=thanos+tzounopoulos&hl=en&as_sdt=0,5

 

Thanks for the info. I am thankful for this man. He seems to be putting in a lot of work. I hope his studies are successful.

 

Prof. Tzounopoulos does not know if RL-81 will be effective for CHRONIC tinnitus. So by the time if and when this may be out in market, all of us here might be out of luck.

 

By the time this is out we're going to be dead. There's no hope.

 

It worked for chronic tinnitus last time.

 

Where do you see that?

 

Tons of people tried it and it worked for them. Search Retigabine in the search bar.

 

Xenon Pharmaceuticals is creating a similar drug targeting the same receptors for rare infant seizure disorders. They're in phase 2 I believe. Obviously not for tinnitus on-label butttttt...

 

Oh yeah, true that!

 

Can somebody please ask Professor Thanos Tzounopoulos, when is Phase 1 starting?

Guy's first and last name start with the letter "T", it is a sign from above. TT.

Why the heck is he still playing with mice? We already KNOW Retigabine worked.

He's been playing with mice for the last 5 years.

 

That's why I love this community, things are happening people. Don't lose heart!

Is it XEN-496? They're in Phase 3 as of this year.

 

Just try not to get visual snow from a drug like this... It sucks. Lol.

 

I think he has to. Retigabine worked but didn't it do some serious organ damage in a lot of people?

 

I don't pretend to know what kinds of regulations there are as to whether drugs are 'new' and require the full pipeline from pre-clinical to Phase 3 but I would assume Prof. Tzounopoulos fallen afoul of something — that means RL-81 needs to be tested thoroughly from the ground up.

He doesn't use it very often but here's his Twitter for those interested:

https://twitter.com/acousticthanos

Where he stated in February that "We Are Getting Closer to a Clinical Trial."

Honestly, he seems like an enthusiastic guy who really wants this to go to trial and work for tinnitus sufferers; medical progress is painfully slow but I'm going to be keeping a close eye on this one.

 

And I know a number of people personally who were helped by Retigabine.

 

Did any of these people get rid of their tinnitus? Did the effects of the drug last after they stopped using it?

 

XEN1101 (focal epilepsy) is in Phase 2 and XEN496 (child epilepsy) is in Phase 3. The estimated end date of the clinical trial for XEN496 is December, 2022.