Prof. Thanos Tzounopoulos Receives $2 Million Grant

Discussion in 'Research News' started by Jack Straw, Dec 4, 2018.

    1. Jcmc

      Jcmc Member

      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      Very Loud Headphones!
      I do not understand how they can tell when the animal has or does not have tinnitus when it is something that is still difficult to verify in humans, knowing that animals do not speak!
       
    2. lymebite
      Vegged out

      lymebite Member Podcast Patron Benefactor

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      My understanding is that the typical approach is to make a sound set at a specific volume level for which animals without tinnitus can hear the sound, and it causes a startle response. For animals with tinnitus, they do not hear the same sound (on account of the tinnitus) and it does not cause a startle response.
       
    3. Pitseleh

      Pitseleh Member

      Location:
      France
      Tinnitus Since:
      2007
      Cause of Tinnitus:
      Unknown
      Basically: rat hears a sound -> gets food.

      Repeat multiple times.

      Rat goes for food when it hears a sound.

      Induce tinnitus.

      Rat goes for food without external stimulus -> rat has tinnitus.
      Rat doesn't go for food without external stimulus -> rat has no tinnitus.

      Tadaaa.
       
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    4. VeryUnfortunate
      Stressed

      VeryUnfortunate Member Benefactor

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Acoustic Trauma
      I have high hopes for this. Anyone have any new news on this by any chance?
       
    5. Jimmyboi

      Jimmyboi Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      Unfortunately not, since we saw a publication last month I imagine it'll be slow going until some clinical trials are hopefully announced.

      However if you check Professor Tzounopoulos' publications this year already, he is a busy one.

      https://scholar.google.com/scholar?as_ylo=2021&q=thanos+tzounopoulos&hl=en&as_sdt=0,5
       
    6. VeryUnfortunate
      Stressed

      VeryUnfortunate Member Benefactor

      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Acoustic Trauma
      Thanks for the info. I am thankful for this man. He seems to be putting in a lot of work. I hope his studies are successful.
       
      • Agree Agree x 1
    7. dan
      Chatty

      dan Member Hall of Fame

      Location:
      Toronto, Canada
      Tinnitus Since:
      06/2011
      Cause of Tinnitus:
      Loud noise
      Prof. Tzounopoulos does not know if RL-81 will be effective for CHRONIC tinnitus. So by the time if and when this may be out in market, all of us here might be out of luck.
       
    8. Snake
      Heartbroken

      Snake Member

      Location:
      Poland
      Tinnitus Since:
      08/2011
      Cause of Tinnitus:
      2011 - Gaming on headphones. 2020 - Severe by breaking glass
      By the time this is out we're going to be dead. There's no hope.
       
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    9. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      It worked for chronic tinnitus last time.
       
    10. Jcmc

      Jcmc Member

      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      Very Loud Headphones!
      Where do you see that?
       
    11. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      Tons of people tried it and it worked for them. Search Retigabine in the search bar.
       
    12. Matchbox
      Wishful

      Matchbox Member

      Location:
      BC Canada
      Tinnitus Since:
      August 2020
      Cause of Tinnitus:
      Noise Induced, Prednisone (drones), Barotrauma (distortions)
      Xenon Pharmaceuticals is creating a similar drug targeting the same receptors for rare infant seizure disorders. They're in phase 2 I believe. Obviously not for tinnitus on-label butttttt...
       
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    13. dan
      Chatty

      dan Member Hall of Fame

      Location:
      Toronto, Canada
      Tinnitus Since:
      06/2011
      Cause of Tinnitus:
      Loud noise
      Oh yeah, true that!
       
    14. dan
      Chatty

      dan Member Hall of Fame

      Location:
      Toronto, Canada
      Tinnitus Since:
      06/2011
      Cause of Tinnitus:
      Loud noise
      Can somebody please ask Professor Thanos Tzounopoulos, when is Phase 1 starting?

      Guy's first and last name start with the letter "T", it is a sign from above. TT.

      Why the heck is he still playing with mice? We already KNOW Retigabine worked.

      He's been playing with mice for the last 5 years.
       
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    15. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      That's why I love this community, things are happening people. Don't lose heart!

      Is it XEN-496? They're in Phase 3 as of this year.
       
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    16. asey20
      Buzzed

      asey20 Member Benefactor

      Location:
      Toronto
      Tinnitus Since:
      July 13, 2020
      Cause of Tinnitus:
      Not sure.
      Just try not to get visual snow from a drug like this... It sucks. Lol.
       
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    17. Tezcatlipoca
      Question it

      Tezcatlipoca Member

      I think he has to. Retigabine worked but didn't it do some serious organ damage in a lot of people?
       
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    18. Jimmyboi

      Jimmyboi Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Unknown
      I don't pretend to know what kinds of regulations there are as to whether drugs are 'new' and require the full pipeline from pre-clinical to Phase 3 but I would assume Prof. Tzounopoulos fallen afoul of something — that means RL-81 needs to be tested thoroughly from the ground up.

      He doesn't use it very often but here's his Twitter for those interested:

      https://twitter.com/acousticthanos

      Where he stated in February that "We Are Getting Closer to a Clinical Trial."

      Honestly, he seems like an enthusiastic guy who really wants this to go to trial and work for tinnitus sufferers; medical progress is painfully slow but I'm going to be keeping a close eye on this one.
       
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    19. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      And I know a number of people personally who were helped by Retigabine.
       
    20. asey20
      Buzzed

      asey20 Member Benefactor

      Location:
      Toronto
      Tinnitus Since:
      July 13, 2020
      Cause of Tinnitus:
      Not sure.
      Did any of these people get rid of their tinnitus? Did the effects of the drug last after they stopped using it?
       
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    21. Zugzug

      Zugzug Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      Autoimmune hyperacusis from Sjogren's Syndrome
      XEN1101 (focal epilepsy) is in Phase 2 and XEN496 (child epilepsy) is in Phase 3. The estimated end date of the clinical trial for XEN496 is December, 2022.
       
      • Like Like x 1
    22. nocticolor
      No Mood

      nocticolor Member

      Location:
      Germany
      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Unknown
      At this point we’ll be able to grow organs in labs successfully before any effective treatment for tinnitus is officially on the market :D
       
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    23. RichieTheKid
      Question it

      RichieTheKid Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Many Different things
      There has to be some unknown herb in the world that can reverse these things.
       
    24. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      With our luck, in the near future... a biotech company will demonstrate the ability to regrow every single part of the human body, all of it... except the cochlea.
       
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    25. nocticolor
      No Mood

      nocticolor Member

      Location:
      Germany
      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Unknown
      Maybe one of these islands where they attack anyone getting close!
      Damn, at that point they should just work on transferring the human psyche to a whole new body. I’ll volunteer as a test subject.
       
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    26. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      Maybe this is why those un-contacted / non-modern peoples have perfect hearing at an old age? Or it's just that they haven't been exposed to city noise, construction, loud music, earbuds, fireworks, airbags... but who am I to know?
       
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    27. nocticolor
      No Mood

      nocticolor Member

      Location:
      Germany
      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Unknown
      That, and the nice teeth. Maybe we’re onto something. Maybe they’re onto something. Too bad it’s too late for us to become hermits. We’re already fucked, and not in the good way.
       
    28. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
      It's NEVER too late to become a hermit.
       
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    29. Aaron91
      Gloomy

      Aaron91 Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      2007
      Cause of Tinnitus:
      Loud music/headphones/concerts - Hyperacusis from motorbike
      This is a guinea pig lab. If there was, we'd know about it by now.
       
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    30. twa
      Busy

      twa Member Benefactor Hall of Fame

      Location:
      US
      Tinnitus Since:
      2017- mild /Sept. 2020-moderate
      Cause of Tinnitus:
      meds/acoustic trauma
      I believe this to a certain degree. I think our auditory systems were not designed to hear the amount of man-made, artificially created sound we hear on a daily basis. If we were to measure the level of sound or decibel output of sounds created in nature, with few exceptions the sounds would be lower in decibels and not at a constant level (I know cicadas, crickets, frogs, etc.). I think the level and the amount of perpetual noise we receive daily is too much for some of our auditory systems.
      From one who has been a hermit lately, it's no fun.
       
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