Prof. Thanos Tzounopoulos Receives $2 Million Grant

Discussion in 'Research News' started by Jack Straw, Dec 4, 2018.

    1. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      If hearing regeneration isn’t here by then, I’ll definitely be going to the doctor to pop XEN496.
       
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    2. Joe72

      Joe72 Member

      Tinnitus Since:
      2014
      Cause of Tinnitus:
      headphones use as a teenager and loud event
      Wow, this lady is super duper smart. The amount of information she covers in such a short time, and by the looks of it right off the top of her head, is astounding. Listening to the lecture is like reading a textbook. Unreal.

      Thank you so much for that info. I never would have thought to go looking for it. The complexity of the ear is mind blowing.
       
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    3. twa
      Studious

      twa Member Benefactor Hall of Fame

      Location:
      US
      Tinnitus Since:
      2017- mild /Sept. 2020-moderate
      Cause of Tinnitus:
      meds/acoustic trauma
      Sounds interesting. I'll check it out when I'm more awake tomorrow.

      twa
       
    4. twa
      Studious

      twa Member Benefactor Hall of Fame

      Location:
      US
      Tinnitus Since:
      2017- mild /Sept. 2020-moderate
      Cause of Tinnitus:
      meds/acoustic trauma
      That's initially how I acquired tinnitus.
       
    5. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      Is there a chemical difference between Dr. Thanos Tzounopoulos' drug and XEN-496?
       
    6. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      I think Dr. Thanos Tzounopoulos' drug is expected to be more potent and have fewer side effects but their mechanisms of action are extremely similar.
       
    7. sssing

      sssing Member Benefactor

      Tinnitus Since:
      2019
      Cause of Tinnitus:
      cold
      Thanks and glad it was useful. Yes, it’s mind-blowing!
       
    8. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      XEN-496 is also expected to be more potent. This is something that Prof. Thanos Tzounopoulos should have been asked.

      Prof. Thanos Tzounopoulos mentioned that he wants to redesign Retigabine/Trobalt, but this is what Xenon is already doing.
       
    9. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      Is there any difference between XEN496 and Trobalt? Trobalt had nasty side effects like visual snow syndrome and organ damage, so if there's no discernible difference then I don't see why people would want to take this medication.
       
    10. Nobody19

      Nobody19 Member Podcast Patron Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      XEN496 is designed specifically to have fewer side effects.
       
    11. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      Trobalt also helped people’s tinnitus and hyperacusis. I think many would accept organ damage for that. I would.
       
      • Agree Agree x 1
    12. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      That's why it was pulled from the market and Xenon redesigned it - to get rid of the nasty side effects.
       
    13. L34

      L34 Member

      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      Unknown, but little dip at 7000 Hz
      Shouldn't we all be very excited about XEN496? I don't think there is much hype about it here, and I know so little about it.

      Maybe worth it to investigate it a bit more? :)
       
    14. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      I don't know how it went under the radar to be honest, it's definitely the first new Retigabine that’s going to make it to market.
       
      • Agree Agree x 1
    15. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      I definitely wouldn't, that could wind up being worse than your original conditions for some temporary relief.
       
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    16. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      Most put all their hopes on regenerative drugs. But these drugs are still in Phase 1 and have some limitations regarding the cause and the severity of hearing loss.
       
    17. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
      Joe Dart's basement
      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      What are you on about? FX-322 is entering its final phase next year--literally confirmed by the CEO.
       
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    18. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      They haven't published their Phase 2 data yet, and we don't know what is going to happen after that.

      They may commercialize their drug fairly quickly.

      However, Xenon drug is still ahead of FX-322.
       
    19. Aaron91
      Gloomy

      Aaron91 Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      2007
      Cause of Tinnitus:
      Loud music/headphones/concerts - Hyperacusis from motorbike
      I think I speak for a lot of people here when I say that the issue with a drug like this is its philosophy. It would act as a kind of band-aid to mask one's symptoms, a bit like how a painkiller can help one's pain but not cure the underlying problem. I know a lot of people would welcome some kind of alleviation to their symptoms, as would I, but I think there's something to be said about the confidence people would have knowing that their ears have been 'restored' to some kind of normality (with drugs such as FX-322 or OTO-413), as opposed to knowing that they remain with damaged ears and the drug is simply masking their symptoms.

      I guess in a way, it also would distort people's personal barometers that help them gauge how their ears are doing, which we have all developed since having these conditions and I think even with restored, healthy ears, none of us plan on giving up those barometers moving forward.
       
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    20. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      When is this Xenon drug expected to be out?
       
    21. L34

      L34 Member

      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      Unknown, but little dip at 7000 Hz
      Very good point, thank you :)

      Yes, you are right, restoration of our hearing is the first priority/wish, and if that is not going to be possible with FX-322, then we could try other things.

      I don't dare to be that optimistic about FX-322, since I don't believe it will help us all, and not as much as we all hope for. But I am of course crossing my fingers and hoping for good results in March :)
       
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    22. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      It's likely we will need to combine FX-322 with a synapse drug e.g., OTO-413 to experience a full reduction in tinnitus but I reckon FX-322 would offer many of us some much-needed relief.
       
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    23. L34

      L34 Member

      Tinnitus Since:
      June 2020
      Cause of Tinnitus:
      Unknown, but little dip at 7000 Hz
      I hope so much you are right :)

      Whatever the price will be for the upcoming treatments, I will try them :)
       
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    24. Diesel

      Diesel Member Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      1-2019
      Cause of Tinnitus:
      20+ Years of Live Music, Motorcycles, and Power Tools
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    25. Aaron91
      Gloomy

      Aaron91 Member Podcast Patron Benefactor Ambassador Advocate

      Tinnitus Since:
      2007
      Cause of Tinnitus:
      Loud music/headphones/concerts - Hyperacusis from motorbike
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    26. Matchbox
      Wishful

      Matchbox Member

      Location:
      BC Canada
      Tinnitus Since:
      August 2020
      Cause of Tinnitus:
      Noise Induced, Prednisone (drones), Barotrauma (distortions)
      The XEN496 drug is based on a completely new design (probably based on machine learning with the computer models we have). I saw its structure once and it is certainly unique.

      Thanos basically threw a Fluorine on Retigabine to enhance its polarity and reactivity and called it a day.

      One will be way less toxic than the other and have different affinities.

      Whatever receptor the XEN496 drug targets it will do with impunity. If it isn't Kv7.1 then its use for tinnitus will be very limited.

      Source: I did a chemistry degree in a previous tinnitus free life.
       
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    27. Keith Handy
      Worried

      Keith Handy Member

      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      Stress + sleep deprivation + noise
      Yeah, ANYBODY could do that! ;)
       
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    28. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
    29. Dizzyhead888

      Dizzyhead888 Member Benefactor

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      unknown
      Seeing as Trobalt/Retigabine is discontinued, can it be found anywhere in the world at this point?
       
    30. Mentos

      Mentos Member Benefactor

      Location:
      Cracow, Poland
      Tinnitus Since:
      03/2015
      Cause of Tinnitus:
      Noise induced, loud rock concert
      Nobody said it’s not going to work on chronic tinnitus. I think it’s impossible to check in animal models if it’s effective in chronic cases, they can only induce tinnitus in an animal and then try to reverse it within limited time.
       
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