Prof. Thanos Tzounopoulos Receives $2 Million Grant

Discussion in 'Research News' started by Jack Straw, Dec 4, 2018.

    1. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Then this allows Sound Pharmaceuticals to get the treatment out and also enables them to not necessarily need to put this through clinical trials for other indications.
       
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    2. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Tinnitus.
       
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    3. wwtsai
      Assassinator

      wwtsai Member Podcast Patron Benefactor

      Location:
      San Francisco
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      Mild (2016) Bothersome (8/20)
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      SNHL
      Have they actually begun the Phase 3 for Meniere's? I couldn't find it on ClinicalTrials.gov. Seems like they're going full steam with the two phase 2 COVID-19 trials which, if on track still, should be done by the end of this year.
       
    4. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Is that a fact?
       
    5. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      Yes, but not everyone reaches receptor tolerance and in some people it takes years to decades.

      Also: if you ever withdrawal from taking benzos taper very, very slowly under a (knowledgeable) doctor's care to minimize rebound tinnitus (sometimes severe). This forum is filled with horror stories, unfortunately.

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213946/

      https://www.benzo.org.uk/busto.htm
       
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    6. Brians81
      Gloomy

      Brians81 Member

      Location:
      Indiana
      Tinnitus Since:
      April 23 2020
      Cause of Tinnitus:
      Noise induce trauma
      How does tinnitus get rebound?
       
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    7. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I know that they are absolutely going ahead with the COVID-19 relief treatment trials.

      However, I am actually not sure about the Meniere's trial. The information I was going off of was what had been provided to me by other users. Even if Sound Pharmaceuticals aren't presently going through the phase 3 trials for Meniere's, it probably won't matter if they get approval for the COVID-19 use. This is because Sound Pharmaceuticals would have the approval for the treatment, then doctors could simply prescribe this treatment off-label for Meniere's.
       
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    8. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

      Tinnitus Since:
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      Benzo withdrawal symptoms (and there are a plethora of them) in general are caused by receptor tolerance or lack of receptor stimulation.

      Dr. Heather Ashton in the UK who was one of the world's benzo withdrawal experts before she passed away described tinnitus, sometimes very severe as a common symptom of benzo withdrawal.

      How it appears to relate to tinnitus is that there are GABA receptors on outer hair cells themselves that help attenuate the glutamate release from sound stimuli. It's easy to imagine impairment of these would impede that attenuation.

      But early on that attenuation effect is why it can be very effective.

      Not everyone obviously gets benzo withdrawal symptoms but it is a known risk and tinnitus worsening is part of that risk.
       
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    9. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
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      It was mentioned to me that the tweaked Retigabine was going to be trialled in Australia next.

      Can anyone enlighten me as to whether this is true, and if so, when and where please?
       
      • Good Question Good Question x 1
    10. Brians81
      Gloomy

      Brians81 Member

      Location:
      Indiana
      Tinnitus Since:
      April 23 2020
      Cause of Tinnitus:
      Noise induce trauma
      Well, at least I know what not to use for my tinnitus. Thanks for the info.
       
    11. Christiaan
      Inspired

      Christiaan Member Podcast Patron Benefactor

      Location:
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      Hi @DebInAustralia, I've asked Dr. Tzounopoulos about possible trials in Australia and elsewhere, but he couldn't say where it would take place. The mail that I've received from him, below, dates March the 5th, 2020.

      ________________________________________________________________________________
      Sorry to learn of you tinnitus

      Hope you feel better soon

      We are currently performing preclinical testing

      Once this is successfully completed, we will move to clinical trials

      Not sure where the clinical trial will take place

      RL-81 was designed to treat noise-induced tinnitus in mice.

      RL-81 was designed to treat the brain after noise-induced tinnitus;

      so it could work even if the auditory nerve is damaged

      Thank you for your kind words.
       
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    12. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I wish we could glean tolerance/withdrawal proclivity genetically like we can do for anti depressant response... just another example of being born too early with this crap.
       
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    13. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Ambassador Hall of Fame Advocate

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      I have wondered if there is a way to do this.

      Maybe if the people with known withdrawal problems sent their genome to 23andMe and then uploaded it to Promethease and looked at their GABA receptor genes, it might point to clues in the most obvious genes (of course there are going to be many other genetic cofactors too). You would need a large sample size.
       
      • Good Question Good Question x 1
    14. Michael01
      Frustrated

      Michael01 Member

      Location:
      Grafton,NSW,Australia.
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      I hope this is so, and soon. I've been trying to get into a study for some time since I learned on how to do so, but have been unsuccessful so far. Doesn't help that most of them are U.S based.
       
    15. sssing

      sssing Member Benefactor

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      cold
      EARssentials 2020: Dr. Catherine Weisz


      This clip explains the mechanisms of how hair cell synapses work. I think it might help you understand Dr. Thanos’ work much better.
       
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    16. sssing

      sssing Member Benefactor

      Tinnitus Since:
      2019
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      cold


      I think he is talking about RL-81? I feel so down because he seems to say it only works for acute cases of noise induced tinnitus. I hope that’s not the case.
       
    17. UHPTS
      Wishful

      UHPTS Member

      Tinnitus Since:
      October 2019
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      No worries. The video is from 2013.
       
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    18. sssing

      sssing Member Benefactor

      Tinnitus Since:
      2019
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      cold
      Thanks. The notes made by @FGG on his Tinnitus Talk Podcast interview helped a lot. I hope his preclinical trials go well. All of us are waiting and hoping.
       
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    19. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
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    20. Tomas80

      Tomas80 Member

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknow. Maybe stress?
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    21. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      The XEN496 is some improved Trobalt from Xenon Pharma. If they are sticking to December 2022 for Phase 3 finishing, then this is actually quite fast as it could be released after that.

      It's not Prof. Thanos Tzounopoulos' drug. That is still in pre-clinical stage and we don't know exactly when clinical trials will start.
       
      • Agree Agree x 1
    22. weab00
      Gloomy

      weab00 Member Benefactor

      Location:
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      Tinnitus Since:
      05/2019
      Cause of Tinnitus:
      some good mf music
      In the grand scheme of things that's not a long time, dude.
       
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    23. Watasha
      No Mood

      Watasha Member Benefactor Advocate

      Tinnitus Since:
      03/2018
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      @Tomas80 I am very sorry to hear of the devastation that this thing of ours has caused you. I encourage you to go over to this thread below and spend 3 minutes to e-mail the American Tinnitus Association and kindly ask that they focus their new found wealth on permanent funding for tinnitus research and not other actives.

      If I am not mistaken, it was seed grant money from the ATA that helped get Prof. Tzounopoulos going with this current prospective pill. Everything you need can be found on the thread. Little actions we take today can compound greatly over time. All the best to you!

      Call to Action: Contact the ATA Right Now — 3 Minutes to Make a Difference
       
    24. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      That’s actually an interesting question and possibly something that could be found in the dark web.
       
    25. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      Is there any hint of a prospective timeline for clinical trials to start?
       
    26. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      I think in May 2020 he said in the Tinnitus Talk Podcast that the preclinical trial would take roughly 1.5 years. So maybe clinical trials would start in 2022?

      Anyway this is far off.

      We can probably first test hearing regeneration drugs and the improved Trobalt from Xenon Pharma.
       
      • Agree Agree x 1
    27. frpp

      frpp Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      Tmj, Nihl, ototoxic drugs, nerve/ vascular issues
      Yeah my money's on that we'll have hearing regenerative drugs long before RL-81 sees Phase 2. I hope RL-81 works well too. With tinnitus we could all use as many treatments and solutions as possible.
       
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    28. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      Do we have any reason to believe XEN496 will be effective for tinnitus, or is it purely speculation based upon the efficacy of Trobalt?
       
    29. Born To Slay
      Depressed

      Born To Slay Member

      Tinnitus Since:
      10/2019
      Cause of Tinnitus:
      Loud concert
      It’s literally the same thing as Trobalt.
       
      • Agree Agree x 1
    30. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor

      Tinnitus Since:
      April 16 2019
      Cause of Tinnitus:
      Nonnatural energy source
      I was blessed to not even be aware that tinnitus was a thing when Trobalt came out and then was pulled, so I'm not very familiar with it, though I've pursued some old posts. It was actually effective for a lot of people (most?)... aside from turning blue and dying and such, right?

      If so, should I be getting excited that there will be another potential treatment in 2022? I count FX-322 and Dr. Susan Shore as possibly maybe sort of being in 2022. If so, 2022 could be the big year for us blessed individuals.
       
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