Prof. Thanos Tzounopoulos Receives $2 Million Grant

Discussion in 'Research News' started by Jack Straw, Dec 4, 2018.

    1. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      Then this allows Sound Pharmaceuticals to get the treatment out and also enables them to not necessarily need to put this through clinical trials for other indications.
       
      • Agree Agree x 1
    2. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Tinnitus.
       
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    3. wwtsai

      wwtsai Member Podcast Patron Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      SNHL
      Have they actually begun the Phase 3 for Meniere's? I couldn't find it on ClinicalTrials.gov. Seems like they're going full steam with the two phase 2 COVID-19 trials which, if on track still, should be done by the end of this year.
       
    4. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
      Cause of Tinnitus:
      Sshl
      Is that a fact?
       
    5. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Yes, but not everyone reaches receptor tolerance and in some people it takes years to decades.

      Also: if you ever withdrawal from taking benzos taper very, very slowly under a (knowledgeable) doctor's care to minimize rebound tinnitus (sometimes severe). This forum is filled with horror stories, unfortunately.

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213946/

      https://www.benzo.org.uk/busto.htm
       
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    6. Brians81
      Gloomy

      Brians81 Member

      Location:
      Indiana
      Tinnitus Since:
      April 23 2020
      Cause of Tinnitus:
      Noise induce trauma
      How does tinnitus get rebound?
       
    7. tommyd87

      tommyd87 Member

      Tinnitus Since:
      1999
      Cause of Tinnitus:
      tmj music
      I know that they are absolutely going ahead with the COVID-19 relief treatment trials.

      However, I am actually not sure about the Meniere's trial. The information I was going off of was what had been provided to me by other users. Even if Sound Pharmaceuticals aren't presently going through the phase 3 trials for Meniere's, it probably won't matter if they get approval for the COVID-19 use. This is because Sound Pharmaceuticals would have the approval for the treatment, then doctors could simply prescribe this treatment off-label for Meniere's.
       
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    8. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Benzo withdrawal symptoms (and there are a plethora of them) in general are caused by receptor tolerance or lack of receptor stimulation.

      Dr. Heather Ashton in the UK who was one of the world's benzo withdrawal experts before she passed away described tinnitus, sometimes very severe as a common symptom of benzo withdrawal.

      How it appears to relate to tinnitus is that there are GABA receptors on outer hair cells themselves that help attenuate the glutamate release from sound stimuli. It's easy to imagine impairment of these would impede that attenuation.

      But early on that attenuation effect is why it can be very effective.

      Not everyone obviously gets benzo withdrawal symptoms but it is a known risk and tinnitus worsening is part of that risk.
       
      • Informative Informative x 2
    9. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      It was mentioned to me that the tweaked Retigabine was going to be trialled in Australia next.

      Can anyone enlighten me as to whether this is true, and if so, when and where please?
       
      • Good Question Good Question x 1
    10. Brians81
      Gloomy

      Brians81 Member

      Location:
      Indiana
      Tinnitus Since:
      April 23 2020
      Cause of Tinnitus:
      Noise induce trauma
      Well, at least I know what not to use for my tinnitus. Thanks for the info.
       
    11. Christiaan
      Vegged out

      Christiaan Member Podcast Patron Benefactor

      Location:
      The Hague, the Netherlands
      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Bloody headphones in 2016,worsened in 2020
      Hi @DebInAustralia, I've asked Dr. Tzounopoulos about possible trials in Australia and elsewhere, but he couldn't say where it would take place. The mail that I've received from him, below, dates March the 5th, 2020.

      ________________________________________________________________________________
      Sorry to learn of you tinnitus

      Hope you feel better soon

      We are currently performing preclinical testing

      Once this is successfully completed, we will move to clinical trials

      Not sure where the clinical trial will take place

      RL-81 was designed to treat noise-induced tinnitus in mice.

      RL-81 was designed to treat the brain after noise-induced tinnitus;

      so it could work even if the auditory nerve is damaged

      Thank you for your kind words.
       
      • Informative Informative x 3
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    12. GBB

      GBB Member

      Location:
      NYC
      Tinnitus Since:
      2020
      Cause of Tinnitus:
      Microsuction / Additional Acoustic Trauma in Close Proximity
      I wish we could glean tolerance/withdrawal proclivity genetically like we can do for anti depressant response... just another example of being born too early with this crap.
       
      • Agree Agree x 4
    13. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I have wondered if there is a way to do this.

      Maybe if the people with known withdrawal problems sent their genome to 23andMe and then uploaded it to Promethease and looked at their GABA receptor genes, it might point to clues in the most obvious genes (of course there are going to be many other genetic cofactors too). You would need a large sample size.
       
      • Good Question Good Question x 1
    14. Michael01
      Frustrated

      Michael01 Member

      Location:
      Grafton,NSW,Australia.
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Unknown
      I hope this is so, and soon. I've been trying to get into a study for some time since I learned on how to do so, but have been unsuccessful so far. Doesn't help that most of them are U.S based.
       

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