Prof. Thanos Tzounopoulos Receives $2 Million Grant

I wonder how RL648_81 entering the clinical phase would affect its supply. I mean, the synthesize instructions are freely available, and there are multiple chemical vendors selling the stuff already. In a paper published last year the Prof said that "further toxicology assessments and a transition to early clinical evaluation are therefore in progress."

I don't know how much of that is true but let's suppose for a minute the toxicology profile of RL648_81 turns out to be relatively "good" (whatever that implicates precisely). Would more online vendors start selling it? Chinese or Indian chemical factories start producing it in bulk? Maybe more research teams start doing experiments with it? I don't really know but maybe the more 'open source' nature of RL648_81 gives it an edge over Xenon's products.

By the way, have you ever considered taking Flupirtine?

 

I have found several anecdotal reports of Quercetin reducing/eliminating tinnitus for some (not on here). If it weren't for a link to a study I stumbled on here suggesting Quercetin is ototoxic, I would be tempted to try it again.

 

Apologies for not getting back to you yet Deb but mojo is low.

From my research Quercetin hits the Kv 7.1 channel, not the Kv 7.2 channel.

Hope you are well.

 

So I've done some quick searches on Google and apparently cannabidiol (CBD) is a Kv2/7.3 channel opener too. A paper published in February 2022 reads that:

Now I'm not a neuroscientist by any means, I'm just copying some interesting remarks from the study so I have no idea about how its 'pharmacokinetic profile' compares to other Kv7 channel openers such as Retigabine, Flupirtine, XEN1101 etc. The potential of CBD oil in treating tinnitus is well known on this forum, as there are numerous threads about people being cured by its administration. I've quickly glanced over some of these threads, the results of people trying CBD oil are very mixed (see some of the comments and the very scientific poll on this thread). I haven't really analyzed these threads in details, so I don't know the cause of this variety in CBD response is yet. One of the causes of the adverse effects of taking CBD oil could be attributed to the purity of the product that is consumed, or in other words, they could be attributed to the THC residue in some of these oils, but that is total speculation on my part

The thread on Retigabine also reported mixed results, but I don't know how they compare to those of CBD oil. Considering hyperacusis, @Willpowered claimed CBD oil gave him temporary relief for an estimated 5-6 hours, but he did say that "[relief] can be maintained with more oil and I think it builds up in your system." @Willpowered hasn't been seen since 2018.

In conclusion, I think this article (see PDF) is a potential bombshell for anyone interested in the works of Tzounopoulos and Xenon Pharmaceuticals. As far as I know the connection between potassium channel activation and cannabidiol hasn't been made on this forum as of yet. CBD could be a promising Kv7-based treatment for tinnitus and noxacusis that is available over the counter (if it's legal in your country).

As you may have read, my experiments with Flupirtine were a total disaster, but I attribute that to its psychoactive properties. Theoretically, CBD is not psychoactive so it should cause less adverse effects in that particular area. I think the Kv7.2/7.3 channel modulation properties of CBD are an important discovery for anyone waiting for the release of XEN1101 and RL-81, particularly those with pain hyperacusis.

Love to hear what y'all think.

 

A role for KCNQ channels on cell-type-specific plasticity in mouse auditory cortex after peripheral damage

A new paper by Prof. Tzounopoulos. It seems to point towards KCNQ potassium channels as a potential pharmaceutical target as has been stated before.

 

Why does all this progress take so goddamn long.

 

$$$.

Just kidding. He's probably working on multiple projects at the same time. He recently released a paper about different versions of RL-81. So he's doing something.

 

Thanos Tzounopoulos is a great guy. I really hope he can find the molecule and is successful in his trials. I would be grateful to think of him as the guy who relieved my tinnitus. Of course, also Dr. Susan Shore. They both represent ethical and the bright side of science.

 

I believe XEN1101 will come to market significantly faster (2-3 years) than any of his versions. But we'll have to wait and see.

 

Totally agree. The latest update by @Hazel made me believe that. It is not bad news. XEN1101 is developed by big company and is advanced in trials. I think it will he easier for them to deal with FDA and commercialization than it is for Thanos. I will have no issues with taking it off-label. After some years off-label usage by all of us, it will lead to official tinnitus related approval.

I'm very optimistic for Dr. Shore/XEN1101 combo. I do not know how to get my life back while waiting for this combo to come out though. I miss music, miss being able to relax and focus.

 

If you were a betting man, do you think XEN1101 is it? From all you've heard and seen, do you think this is the one?

 

Keep an eye also on Biohaven - BHV7000/7010. They are moving aggressively in this space with an expedited trial schedule, a product they claim is better than XEN1101 and have indicated the possibility of trialing it for other conditions later.

See the BHV7000 thread for more information.

 

I don't know. We won't know for certain unless people try it. It's not free of side effects, either. Visual snow is a dangerous potential side effect of potassium channel openers.

 

Curious why a majority of people with visual snow also have tinnitus - 60% I believe. Not sure about the relationship, but a major factor that is not fully understood.

 

And also floaters. I myself developed visual snow and started noticing a big increase in floaters (from 2-3 I always had, to around 10-15) in a few weeks since tinnitus onset.