Prof. Thanos Tzounopoulos Receives $2 Million Grant

Discussion in 'Research News' started by Jack Straw, Dec 4, 2018.

    1. StoneInFocus
      Badass

      StoneInFocus Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Hearing damage, ear infections
      I wonder how RL648_81 entering the clinical phase would affect its supply. I mean, the synthesize instructions are freely available, and there are multiple chemical vendors selling the stuff already. In a paper published last year the Prof said that "further toxicology assessments and a transition to early clinical evaluation are therefore in progress."

      I don't know how much of that is true but let's suppose for a minute the toxicology profile of RL648_81 turns out to be relatively "good" (whatever that implicates precisely). Would more online vendors start selling it? Chinese or Indian chemical factories start producing it in bulk? Maybe more research teams start doing experiments with it? I don't really know but maybe the more 'open source' nature of RL648_81 gives it an edge over Xenon's products.

      By the way, have you ever considered taking Flupirtine?
       
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    2. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      I have found several anecdotal reports of Quercetin reducing/eliminating tinnitus for some (not on here). If it weren't for a link to a study I stumbled on here suggesting Quercetin is ototoxic, I would be tempted to try it again.
       
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    3. Padraigh Griffin

      Padraigh Griffin Member Benefactor

      Tinnitus Since:
      05/2020
      Cause of Tinnitus:
      Unknown/Stress
      Apologies for not getting back to you yet Deb but mojo is low.

      From my research Quercetin hits the Kv 7.1 channel, not the Kv 7.2 channel.

      Hope you are well.
       
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    4. StoneInFocus
      Badass

      StoneInFocus Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Hearing damage, ear infections
      So I've done some quick searches on Google and apparently cannabidiol (CBD) is a Kv2/7.3 channel opener too. A paper published in February 2022 reads that:
      Now I'm not a neuroscientist by any means, I'm just copying some interesting remarks from the study so I have no idea about how its 'pharmacokinetic profile' compares to other Kv7 channel openers such as Retigabine, Flupirtine, XEN1101 etc. The potential of CBD oil in treating tinnitus is well known on this forum, as there are numerous threads about people being cured by its administration. I've quickly glanced over some of these threads, the results of people trying CBD oil are very mixed (see some of the comments and the very scientific poll on this thread). I haven't really analyzed these threads in details, so I don't know the cause of this variety in CBD response is yet. One of the causes of the adverse effects of taking CBD oil could be attributed to the purity of the product that is consumed, or in other words, they could be attributed to the THC residue in some of these oils, but that is total speculation on my part

      The thread on Retigabine also reported mixed results, but I don't know how they compare to those of CBD oil. Considering hyperacusis, @Willpowered claimed CBD oil gave him temporary relief for an estimated 5-6 hours, but he did say that "[relief] can be maintained with more oil and I think it builds up in your system." @Willpowered hasn't been seen since 2018.

      In conclusion, I think this article (see PDF) is a potential bombshell for anyone interested in the works of Tzounopoulos and Xenon Pharmaceuticals. As far as I know the connection between potassium channel activation and cannabidiol hasn't been made on this forum as of yet. CBD could be a promising Kv7-based treatment for tinnitus and noxacusis that is available over the counter (if it's legal in your country).

      As you may have read, my experiments with Flupirtine were a total disaster, but I attribute that to its psychoactive properties. Theoretically, CBD is not psychoactive so it should cause less adverse effects in that particular area. I think the Kv7.2/7.3 channel modulation properties of CBD are an important discovery for anyone waiting for the release of XEN1101 and RL-81, particularly those with pain hyperacusis.

      Love to hear what y'all think.
       

      Attached Files:

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    5. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
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    6. KoolKat
      Inactive

      KoolKat Member

      Location:
      USA
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      HeadPhones/ Noise induced
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    7. AnthonyMcDonald
      Confused

      AnthonyMcDonald Member

      Location:
      Russia
      Tinnitus Since:
      06/2021
      Cause of Tinnitus:
      Noise induced
      $$$.

      Just kidding. He's probably working on multiple projects at the same time. He recently released a paper about different versions of RL-81. So he's doing something.
       
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    8. Hazel
      Dreaming

      Hazel Director Staff Podcast Patron Benefactor Hall of Fame Advocate

      Location:
      the Netherlands
      Tinnitus Since:
      10/2017
      Cause of Tinnitus:
      one-sided hearing loss (of unknown origin)
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    9. Amv

      Amv Member Benefactor

      Tinnitus Since:
      07/2017
      Cause of Tinnitus:
      -
      Thanos Tzounopoulos is a great guy. I really hope he can find the molecule and is successful in his trials. I would be grateful to think of him as the guy who relieved my tinnitus. Of course, also Dr. Susan Shore. They both represent ethical and the bright side of science.
       
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    10. AnthonyMcDonald
      Confused

      AnthonyMcDonald Member

      Location:
      Russia
      Tinnitus Since:
      06/2021
      Cause of Tinnitus:
      Noise induced
      I believe XEN1101 will come to market significantly faster (2-3 years) than any of his versions. But we'll have to wait and see.
       
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    11. awake 44
      Angelic

      awake 44 Member

      Tinnitus Since:
      02/2022
      Cause of Tinnitus:
      Years of playing in heavy metal band.
      Totally agree. The latest update by @Hazel made me believe that. It is not bad news. XEN1101 is developed by big company and is advanced in trials. I think it will he easier for them to deal with FDA and commercialization than it is for Thanos. I will have no issues with taking it off-label. After some years off-label usage by all of us, it will lead to official tinnitus related approval.

      I'm very optimistic for Dr. Shore/XEN1101 combo. I do not know how to get my life back while waiting for this combo to come out though. I miss music, miss being able to relax and focus.
       
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    12. KoolKat
      Inactive

      KoolKat Member

      Location:
      USA
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      HeadPhones/ Noise induced
      If you were a betting man, do you think XEN1101 is it? From all you've heard and seen, do you think this is the one?
       
    13. ploughna

      ploughna Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      motor racing and power tools
      Keep an eye also on Biohaven - BHV7000/7010. They are moving aggressively in this space with an expedited trial schedule, a product they claim is better than XEN1101 and have indicated the possibility of trialing it for other conditions later.

      See the BHV7000 thread for more information.
       
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    14. AnthonyMcDonald
      Confused

      AnthonyMcDonald Member

      Location:
      Russia
      Tinnitus Since:
      06/2021
      Cause of Tinnitus:
      Noise induced
      I don't know. We won't know for certain unless people try it. It's not free of side effects, either. Visual snow is a dangerous potential side effect of potassium channel openers.
       
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    15. Pivot10

      Pivot10 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Skeet Shooting
      Curious why a majority of people with visual snow also have tinnitus - 60% I believe. Not sure about the relationship, but a major factor that is not fully understood.
       
    16. DimLeb

      DimLeb Member

      Tinnitus Since:
      03/2021
      Cause of Tinnitus:
      Idiopathic Cochleopathy or Maybe Loud Music
      And also floaters. I myself developed visual snow and started noticing a big increase in floaters (from 2-3 I always had, to around 10-15) in a few weeks since tinnitus onset.
       
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