Vitamin Supplement (Nicotinamide Riboside) Successfully Prevents Noise-Induced Hearing Loss

Joe Rogan Experience #1234 - David Sinclair

David Sinclair takes NMN/Resveratrol together. And if Sinclair does something, it's right.

NR is a precursor molecule to NMN, there's literally no difference but the price. NR is better economically and it's also been tested for safety in humans. The only difference is NR acts as a prodrug to NMN.

NMN is a waste of money since it’s far more expensive and just does the same thing. The only difference between them is your body converts NR into NMN, which then gets converted into NAD+

I think David just takes it because he has a ton stored away from trials.

 

Thought I would mention that I'd been taking NR (and Pterostilbene) for a good two years before I experienced sudden hearing loss and tinnitus, via Elysium's Basis supplement, which I haven't seen mentioned in this thread surprisingly. Not that I've read every single comment. The hearing loss/tinnitus arrived this spring, about a month after recovering from walking pneumonia though I'm told a link cannot be 100% established.

I'd certainly like to think that the NAD+ precursor NR will slowly help me recover, at least somewhat, from these conditions, but during this period of course it hasn't.

 

The Niacinamide 500mg I am using is about 1/10 of the price of NR. Why should I still buy NR?
(Bear over with me as I am no pharmacist and value very much a few simple explanatory sentences).

 

Because Niacin doesn't raise NAD+ to any extent whatsoever.

 

Ok. I`ve read the whole thread. You have had success with it and write good posts. I will try it - probably with this Resveratrol: https://www.iherb.com/pr/Jarrow-For...rgy-200-mg-Total-Resveratrol-60-Tablets/18953
and this NR: https://www.lifeextensioneurope.com/catalogsearch/result/?q=Resveratrol

 

I might go for Tru Niagen NR to try to copy the success. To be sure to get the authentic NR I am best of buying from this place? (even if I live in europe)..
https://www.truniagen.com/product_page.html

 

For those of you taking NR at the moment. It’s usually 2 pills per day. Do you take both pills in the morning or do you separate the dosage like 1 pill in the morning and 1 pill at night?

@Heinrich_S7 @vttbx @FGG

 

Currently taking 2 pills twice a day here.

 

What time do you take the pills?

 

With breakfast and dinner. Varies a little day to day but between 7 to 9am for first dose and 6 to 8pm for second. I'm bad at being precise with my supplement timing, in general.

 

So, have you had an audiogram to confirm your improvements?

 

I am 78 and have had continuous tinnitus for more than 35 years. I keep healthy by a keto diet, intermittent fasting and exercise. I have tried everything to reduce tinnitus - including sound therapy, TMJ work. all types of supplements,Vagus Nerve Stimulation etc.

After reading David Sinclair's book "Lifespan Why we Age - and Why We Don't Have To" I started the protocol two weeks ago. 900mgs of NR and one gram of Resveratrol with a little oil every morning.

Within a few days I noticed a dramatic increase in energy. And totally unexpectedly on the third day I suddenly noticed hearing blessed SILENCE, my tinnitus had vanished for the first time in 35 years!
In the last 2 weeks it has briefly returned but soon disappears again. So I will keep monitoring it over the next months and years.

Don

 

Are you taking the 900mg of NR at once in the morning with your Resveratrol?

 

Dr. Sinclair says the any of the NAD boosters can affect your sleep when taken in the evening. It does to me so I only take them in the morning.

 

Interesting. I've never tried that high of a dosage NR. Are you taking it empty stomach plus oil?

 

I separate the dose because I’m worried about side effects but I may do this in the future and take both pills in the morning.

 

Hi!

I have read the thread and I have a question. For this treatment, is it necessary to take 2 tablets of NR a day and another one of Resveratrol? Is it necessary to combine both or could I just take NR?

Forgive my poor English

 

I think I'm going to abandon the half dozen supplements I've tried with no observable benefits, and start buying NR instead (along with my NAC)

 

I can say that this doesn't protect against hearing loss. I was on this for four months when a woman screamed in my ear, and I still got a threshold shift.

Edit: I was actually taking around 500 mg a day with Resveratrol. Did not help me at all with tinnitus, and unfortunately didn't protect me from unexpected sounds. Still have aural fullness from the event which was over a week ago.

 

I stopped all other supplements about a week ago and started NR 2 days ago 300mg/daily. Yesterday was a a raging tinnitus day, today is as quiet as I get. I'll throw in updates as I go along.

 

I’ve also been noticing tinnitus fluctuations as well while taking NR. I think it could be a sign of healing and restoring.

Do you take 2 tablets in the morning or do you separate the dosage.

 

No one knows (I don't think). I think we all take different doses.

 

But did it make you feel more youthful and energetic?

 

I've got sleep issues so I am taking 2 tabs in the AM. Honestly my Tinnitus tends to go on 2-3 days bad peaking late in the cycle then moderating. So though this day is a good one, it is not unusual for me to experience fluctuations before starting NR.

We'll see fingers crossed

 

I'm 21, so I don't think it would make a difference.

 

We actually don’t need a ton of NR to achieve the levels of NAD+ we desire. I remember reading somewhere that more isn’t better in this case as some online chemist explained that it strips methyl groups (?) or something which you can counter with simple creatine monohydrate, which is the cheapest weightlifting/cognitive supplement known to man. Sorry I can’t provide specifics or find this, but I take half a capsule of TruNiagen sublingually before I go into something I anticipate to be noisy/loud.

 

If that's the case I shouldn't of got nihl as I had drank a skinful while watching the fckg band

 

In order to cause breakdown of methyl group you'd have to take 2g per day for an extended period of time. I've only ever taken 125-250mg. You'd need to take a colossal dose.

 

This apparently helped me the first time I used it after getting a spike although I’m sure that the spike was stress induced. This time the spike I’m sure is noise induced and this supplement didn’t work this time round.

 

Sorry for the late answer. You need to ask @Heinrich_S7 about that. I take one NR 300 mg and two 100 mg of Reservatrol tablets pr day.

I started taking Webber Naturals Reservatrol 200/25 mg with Grape seed, but I found that they only have 20% ie 40mg of trans-reservatrol in them (so I switched to 2*100 mg MRM pure Trans-Reservatrol) @Heinrich_S7 are you aware of this?

I take these daily now, but the most spectacular results I get now come from my DIY LLLT.