My Trip to Bangkok: Stem Cell Treatment [Comments]

Discussion in 'Treatments' started by Markku, Aug 18, 2013.

    1. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      Stem Cell 21 primarily uses mesenchymal stem cells, though I’m told they will have induced pluripotent stem cells in 2020. Further, their delivery sites can include the ear, nasal passages and systemic circulation. This Dallas one looks like systemic only, and with poorer choices for treating tinnitus (adipose and bone marrow). I doubt you would get any benefit for tinnitus from them.
       
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    2. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      Until the US allow scientifics to fully research stem cell treatments to their full potential there will be no progress on this field. It is a shame that religion and absurd beliefs hamper scientific progress and erase the slim hope people who suffer from a lot of diseases and health conditions may have.
       
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    3. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      You're talking about embryonic stem cells. The absurd beliefs your talking about are the belief that little babies in the womb should not be violently dismembered and ripped out. Guess what? They don't even need to end the life of an innocent to get embryonic stem cells anymore so cool it with the bloodlust.

      https://news.harvard.edu/gazette/st...s-create-embryonic-stem-cells-without-embryo/
       
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    4. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      I meant religion in general.
       
    5. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Why don't you like religion in general?
       
    6. Juan

      Juan Member

      Tinnitus Since:
      08/2014
      Cause of Tinnitus:
      Several causes
      It hampers progress.
       
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    7. Rafaa

      Rafaa Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Who knows? I have Patulous ET and ETD + Other things
      @attheedgeofscience

      Thanks for sharing your experiences. It is interesting you are able to breathe better through your nose. Do you have any scientific theory as to why? It seems it could have regrown damaged cilia allowing better passage of mucus and pathogens from your sinuses. Or it could be the nerves in sinuses were repaired so they perform better. Interested in your thoughts.
       
    8. Sevv

      Sevv Member Benefactor

      Tinnitus Since:
      12.04.2019
      Cause of Tinnitus:
      Loud concert
      Sorry to crush the hope, but I'm not so sure if iPSCs will be an option. I read the following in a study:

      The basic paradigm in the use of PSCs for cell therapy purposes is that they are first differentiated into the desired cell types of interest, and the resulting specialized tissue-specific cells are then transplanted as cell suspensions or more complex tissue constructs into patients. The differentiation step is crucial because if proliferating, undifferentiated PSCs are directly injected, they would form tumors called teratomas due to their highly proliferative nature and broad differentiation potential. (https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1455-y).
      So it seems you can't just inject iPSCs into the ear because of tumor risk if I understand this correctly.
       
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    9. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      You do. They have to be induced, which can be successfully done, but they never replied to my email about whether they can do it.
       
    10. Sevv

      Sevv Member Benefactor

      Tinnitus Since:
      12.04.2019
      Cause of Tinnitus:
      Loud concert
      If I unterstand it correctly you would first have to make iPSCs (which is mostly established by now how to do it, although still quite complicated), but then you would have to differentiate them into hair cells and then inject them so you don't get teratoma (man they are disgusting :D). But I don't know if such hair cells would integrate into the cochlea in the correct way. FX-322 seems more precise in that matter. Although we can't ignore that stem cells have benefited other users here before (and I've added them to the list of my options in the case I can't deal with my tinnitus anymore, though I'm waiting a couple months/years first to see whether I can habituate to this new louder noise). :) But umbilical cord blood stem cells, the next best thing after IPSCs, are multipotent stem cells and not pluripotent, so they can't proliferate without limit, so there's little / no risk with tumor formation.
       
    11. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
      All I know is Ozzy Osbourne apparently is doing much better after Stem Cell treatment in Panama for Parkinson’s, so there must be something promising to it.

      I’m hoping the Coronavirus exposes the lack of treatment and speed of cures due to FDA red tape, trials at a snail pace, and ineffective medicine. Sad but true, it's time for the US Gov to look at where the money is really going and start questioning how come since the dawn of time we still can’t cure the common cold. Unfortunately it takes a disaster sometimes to change the status quo.
       
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    12. Zaimon

      Zaimon Member

      Tinnitus Since:
      04/2020
      Cause of Tinnitus:
      Sudden Hearing Loss
      Î am curious... The last entry was in 2013... How is @attheedgeofscience now? Did those stem cells really help?
       
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    13. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      He still purports to be fine with minimal tinnitus. He is still on here every once in a while.
       
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    14. Pharz

      Pharz Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Exposure to loud noise
      So happy to know that someone has been almost cured! Almost 8 years have passed since the beginning of this thread, I hope the science has improved and the treatments are somewhat cheaper and more accessible.

      Does anybody have any update on these stem cell treatments?
       
    15. GBB

      GBB Member Hall of Fame

      Location:
      NYC
      Tinnitus Since:
      2016-2019 (Mild, Cured) 8/2020 (Severe)
      Cause of Tinnitus:
      Virus / Microsuction / Acoustic Trauma
      I think the notion that stem cell therapy is still in its infancy holds true across most of healthcare - if you do get stem cell treatment, it's more of a shotgun approach to see what sticks.
       
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    16. Pharz

      Pharz Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Exposure to loud noise
      I read somewhere that the problem with stem cell therapy is uncontrollable reproduction of the injected cells and hence cancer, do you perhaps know if this problem has been solved throughout these years?
       
    17. Lukee

      Lukee Member

      Tinnitus Since:
      01/2021
      Cause of Tinnitus:
      Breathing Exercise
      Reports of cancer from SCs are rare in general. There actually isn’t too much scientific evidence proving SCs exacerbate cancer growth and it’s a theory for the most part. The thing with SCs is that it’s difficult to target a specific area or malady with them and the shotgun metaphor is likely accurate. Clinics do things to try and help along the targeted use of SCs but in reality it helps very little. Mostly, SCs will go where they are needed which is why sometimes people with comorbidities see improvements in many areas while getting treatment. I believe that SCs can help things like ear disorders but you take a gamble as to how much improvement you will see.

      Stem Cell therapy gets a bad rap from the FDA because it’s unregulated and many clinics performing these therapies are ripping off their patients and injecting potentially harmful substances. I have read a story about one clinic injecting people with steroids, albumin and other medications that would make the patient feel like a kid again for the proceeding days but shortly after fall back into the same chronic condition.

      If you have the means and go to a reputable clinic, you will likely get some improvement in any ear disorder but no one can tell you how much. The real future of stem cells is using mRNA to reprogram them to cure chronic conditions. This is happening right now. We have effectively “cured” sickle cell disease, beta thalassemia, pyruvate kinase disease, etc. These blood disorders were basically a life sentence before but over the last 12 months, science has used SC and mRNA to rewrite DNA and remove genetic errors. This is the future of medicine. Unfortunately for the US (and Canada) we are still very far behind in this technology mainly because of the political issues surrounding embryonic stem cells. Today MSC can be used but the technology as a whole is far behind that of other countries. This is why people are going to Bangkok to get SC treatment for their ears or to Germany to get cancer treatment (which I believe BioNtech will have cures for some types of cancers in the next 24 months).
       
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    18. Pharz

      Pharz Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Exposure to loud noise
      Unfortunately after getting tinnitus I realised how many scams there are for different illnesses around the world. I guess waiting is the only option. I hope someone finds the Penicillin of the tinnitus soon.
       
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