Prof. Thanos Tzounopoulos Receives $2 Million Grant

It was more of a joke lol

 

I saw that before and checked the exact same thing, I couldn't find a connection between them either.

 

Nah I really do hate to be negative, though. It doesn’t serve any purpose.

 

I even cross referenced Twitter followers. I'm going to keep stalking though because it seems *too* coincidental imo.

 

Unfortunately, Knopp, who seems to be working faster, is not labeling tinnitus as a primary concern of theirs, but rather epileptic encephalopathy, etc.

https://knoppbio.com/news/knopp-bio...merican-epilepsy-societys-2019-annual-meeting

Edit: They squeezed tinnitus in here.

 

So I came across this paper tonight from 2016 by a researcher from Johns Hopkins which discusses the role of the Type 2 nerve fibers as pain receptors in the cochlea, which, as we've come to learn in recent years, could point to the pathology underlying pain hyperacusis. An interesting snippet from the abstract:

"Exposure to the KCNQ channel activator retigabine suppressed the type 2 fiber's response to hair cell damage. Type 2 afferents may be the cochlea's nociceptors, prompting avoidance of further damage to the irreparable inner ear."

Interesting, perhaps suggesting that retigabine could be a potential therapy for pain hyperacusis?
https://jscholarship.library.jhu.edu/handle/1774.2/40719

 

I wonder if it's similar to this drug which has currently completed Phase 2 clinical trials
https://www.xenon-pharma.com/product-pipeline/xen496-for-epilepsy/

 

They work on the exact same channels. No listed use for tinnitus though...

 

https://eyeandear.org/2019/08/developing-a-cure-for-tinnitus/

Timeline for action is coming up. Let’s go Thanos.

http://medschool.creighton.edu/biomedicalsciences/2020belluccisymposium/

Lots of speakers here including Thanos.

 

Very encouraging! I wonder if the development of this drug could also potentially target hyperacusis as well as T given that there was a paper showing that retigabine suppressed the type 2 nerve fibers' (pain fibers) response. And it looks like they're trying to reformulate it so it's more effective and carries fewer side effects.

Good symposium lineup too

 

Lol dude looks like Goldblum in Jurassic Park.

 

Is there a way for Tinnitus Hub to attend to this symposium?

 

This drug is currently in preclinical test. Does somebody know when first results of this test can be expected?

 

Received this message from Dr Thanos today (15 March, 2020)

I am very sorry to learn of your tinnitus


Regarding our efforts: We currently perform preclinical studies, including toxicology, pharmacokinetics, metabolism etc.

We are encouraged by our research results so far

We expect to launch a clinical trial once preclinical studies are successfully completed

Unable predict the exact timeline – but we are committed it.


Thank you for your kind word and encouragement

 

Thanks for the update. Probably this is one of the more promising drugs as Trobalt has already shown to quieten tinnitus. But hopefully Dr. Thanos's drug has not the same side effects as Trobalt: Blue skin, impairment of vision, ...

 

Isn’t there a new improved version of Trobalt in development?

 

Allegedly.

 

Yes. It is in pre clinical test:

https://www.tinnitustalk.com/thread...-research-center-pittsburgh-university.33271/