Prof. Thanos Tzounopoulos Receives $2 Million Grant

Discussion in 'Research News' started by Jack Straw, Dec 4, 2018.

    1. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      It was more of a joke lol
       
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    2. ChrisBoyMonkey

      ChrisBoyMonkey Member Podcast Patron

      Location:
      US
      Tinnitus Since:
      2019
      Cause of Tinnitus:
      Noise
      I saw that before and checked the exact same thing, I couldn't find a connection between them either.
       
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    3. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
      Nah I really do hate to be negative, though. It doesn’t serve any purpose.
       
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    4. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      I even cross referenced Twitter followers. I'm going to keep stalking though because it seems *too* coincidental imo.
       
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    5. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma

      Attached Files:

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    6. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      So I came across this paper tonight from 2016 by a researcher from Johns Hopkins which discusses the role of the Type 2 nerve fibers as pain receptors in the cochlea, which, as we've come to learn in recent years, could point to the pathology underlying pain hyperacusis. An interesting snippet from the abstract:

      "Exposure to the KCNQ channel activator retigabine suppressed the type 2 fiber's response to hair cell damage. Type 2 afferents may be the cochlea's nociceptors, prompting avoidance of further damage to the irreparable inner ear."

      Interesting, perhaps suggesting that retigabine could be a potential therapy for pain hyperacusis?
      https://jscholarship.library.jhu.edu/handle/1774.2/40719
       
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    7. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
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    8. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
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    9. Piney

      Piney Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      Shingles virus
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    10. serendipity1996
      No Mood

      serendipity1996 Member Podcast Patron Hall of Fame

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Unknown but suspect noise-induced
      Very encouraging! I wonder if the development of this drug could also potentially target hyperacusis as well as T given that there was a paper showing that retigabine suppressed the type 2 nerve fibers' (pain fibers) response. And it looks like they're trying to reformulate it so it's more effective and carries fewer side effects.

      Good symposium lineup too
       
    11. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

      Location:
      NE Ohio, USA
      Tinnitus Since:
      July 2019
      Cause of Tinnitus:
      Acoustic trauma
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    12. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
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    13. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      This drug is currently in preclinical test. Does somebody know when first results of this test can be expected?
       
    14. JJ4211

      JJ4211 Member

      Tinnitus Since:
      January, 2019
      Cause of Tinnitus:
      Unknown
      Received this message from Dr Thanos today (15 March, 2020)

      I am very sorry to learn of your tinnitus


      Regarding our efforts: We currently perform preclinical studies, including toxicology, pharmacokinetics, metabolism etc.

      We are encouraged by our research results so far

      We expect to launch a clinical trial once preclinical studies are successfully completed

      Unable predict the exact timeline – but we are committed it.


      Thank you for your kind word and encouragement
       
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    15. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      Thanks for the update. Probably this is one of the more promising drugs as Trobalt has already shown to quieten tinnitus. But hopefully Dr. Thanos's drug has not the same side effects as Trobalt: Blue skin, impairment of vision, ...
       
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    16. Karl28
      No Mood

      Karl28 Member

      Location:
      Melbourne
      Tinnitus Since:
      2001 bad since 2015
      Cause of Tinnitus:
      Loud music via headphones
      Isn’t there a new improved version of Trobalt in development?
       
    17. spedgas
      Gloomy

      spedgas Member Benefactor

      Tinnitus Since:
      09/2018
      Cause of Tinnitus:
      Unknown
      Allegedly.
       
    18. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
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    19. lymebite
      Vegged out

      lymebite Member Podcast Patron Benefactor

      Location:
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    20. xyz
      Alienated

      xyz Member

      Location:
      Germany
      Tinnitus Since:
      2006 mild T 2019 T worsening H onset
      Cause of Tinnitus:
      unknown / probably noise induced
      Thanks for the info. I registered for tomorrow's webinar and send them these questions
      • When are clinical trials expected to start?
      • Is RL-81 also supposed to help pain hyperacusis?
      • Since RL-81 is a reformulation of Trobalt, what is done to prevent that it does not have the same side effects?
      Let's see what Dr. Tzounopoulos says.
       
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    21. Joly

      Joly Member

      Tinnitus Since:
      22/08/2019
      Cause of Tinnitus:
      Traumatisme sonore
      Come on Prof. Tzounopoulos, yes you can!!! We would like a piece of good news.
       
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    22. Frédéric

      Frédéric Member Podcast Patron Benefactor Advocate

      Location:
      Marseille, France
      Tinnitus Since:
      11/19/2012
      Cause of Tinnitus:
      acoustic trauma
      I hope someone will record the webinar. I can't.
       
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    23. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
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      Multi-factorial
      I had some trouble understanding parts of this since there were no captions but what I gathered:

      --Clinical trials are coming within the next year and a half.

      --Some (or all?) will be in Australia. Anyone understand this better?

      --This is just a personal annoyance but some researchers don't appear know the difference between loudness hyperacusis and noxacusis or didn't appear to understand the question in the Q and A very well. Dr. Tzounopoulos expressed that he wants to study hyperacusis, too, but it wasn't clear if they understood the question in regards to "pain hyperacusis" or if he meant loudness.

      --Dr. Tzounopoulos mentioned that tinnitus is due to cochlea injury in the vast majority of people (Schizophrenia related hearing disorders were listed as an exception that occurs with possibly a direct insult to the brain first). His method seeks to normalize the brain's response to that damage by modulating potassium ion channels. The theory is that opening these channels will make the brain match the lack of input after damage with the brain's "prediction" (which is a normal brain function that is being hampered by cochlear damage).

      --Dr. Tzounopoulos does not think the pill would have to be taken indefinitely.

      --It appears they want to test on more recent tinnitus first (eg. 6 months) because they already know from rodents they can prevent tinnitus from becoming permanent but they hope to eventually extend out the time frame.

      --They are very concerned with making sure their drug is much less toxic that Trobalt.

      Did I get anything wrong? Miss anything important?
       
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    24. Lucifer

      Lucifer Member Podcast Patron Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
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      Cause of Tinnitus:
      Ear Infection
      Clinical trials in Australia. That’s shocking. I wouldn’t have expected they would do clinical trials there. I wonder why they would choose to do clinical trials there and not USA.
       
    25. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      Just wanted to add that I believe he said they used a twice a day dosing schedule for only 2 days and it worked even 4 weeks after onset. But hopefully someone can confirm.

      Even if their final dosing ends up being longer I don’t think we’ll be looking at the multi-month dosing regiments that people were experimenting with when it came to Trobalt.
       
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    26. ASilverLight
      In pain

      ASilverLight Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Probably noise, stress and a neck injury.
      I wonder what this means for other causes. Obviously treating underlying conditions is the first route to go down, but if that doesn't work (eg brains not adjusting accordingly anymore), how effective would it be?

      Or, those with damage elsewhere in their ears? If it's targeting the brain's abnormal response to (any) damage within the auditory pathway, I hope it works for those without clear cochlear injuries too...

      But time will tell. I do hope it'll be available and effective to those with chronic tinnitus too.
       
    27. FGG
      No Mood

      FGG Member Podcast Patron Benefactor Hall of Fame Advocate

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Unless you have TMJ or a head injury, you likely do in fact have cochlear damage that doesn't show up on a standard audiogram.
       
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    28. Don Tinny

      Don Tinny Member

      Location:
      Argentina
      Tinnitus Since:
      2017 (worsening)
      Cause of Tinnitus:
      Loud concert with ear plugs
      That sounds good. Bad side effects usually appear when you take a drug for a long time.
       
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    29. ASilverLight
      In pain

      ASilverLight Member Benefactor

      Tinnitus Since:
      01/2020
      Cause of Tinnitus:
      Probably noise, stress and a neck injury.
      I do have a neck injury and some sinus issues going on but I don't completely rule out noise/cochlear damage.
       
    30. HootOwl

      HootOwl Member Podcast Patron Benefactor Advocate

      Location:
      California
      Tinnitus Since:
      2009
      Cause of Tinnitus:
      Explanation in About You
      The good news is better diagnostics tools are on the horizon. Harvard (https://stankovic.hms.harvard.edu/optical-imaging-inner-ear) and another Ivy League - who escapes me at the moment - are both working diligently to address this.

      I think 10-15 years people will be getting inner ear images routinely the same way we now get MRIs and CT scans.
       
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